重点实验室成果目录
发布时间：2023-01-12文章来源：药学院 浏览次数：
近年来发表的论文
1.Ri-Zhen Huang#, Xiao-Teng Jing#, Xiao-Chao Huang, Yingming Pan, Yilin Fang, Guibin Liang, Zhixin Liao, Hengshan Wang*, Zhenfeng Chen*, Ye Zhang*, Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3, Journal of Medicinal Chemistry, 2020, DOI: 10.1021/acs.jmedchem.9b01386.
2.Gui-Bin Liang#, Yan-Cheng Yu#, Jian-Hua Wei, Wen-Bin Kuang, Zhen-Feng Chen*, Ye Zhang*, Design, synthesis and biological evaluation of naphthalenebenzimidizole platinum (II) complexes as potential antitumor agents, European Journal of Medicinal Chemistry, 2020, 188, 112033.
3.Yang-Qing Huang#, Jian-Dong Yuan#, Hai-Feng Ding, Yun-Song Song, Gang Qian, Jia-Li Wang, Min Ji*, Ye Zhang*, Design, synthesis and antitumor activity of a novel PEG-A6-conjugated irinotecan derivative, Bioorganic & Medicinal Chemistry Letters, 2019, DOI: 10.1016/j.bmcl.2019.126847.
4.Hui Zhong, Jia Zhou?*, Xiao-Hong An, Ying-Rong Hua, Yi-Fan Lai, Rui Zhang, Owais Ahmad, Ye Zhang?*, Jing Shang?*, Natural product-based design, synthesis and biological evaluation of 2′,3,4,4′-tetrahydrochalcone analogues as antivitiligo agents, Bioorganic Chemistry, 2019, 87, 523-533.
5.Yang-Qing Huang, Jian-Dong Yuan, Hai-Feng Ding, Yun-Song Song, Gang Qian, Jia-Li Wang, Min Ji*, Ye Zhang*, Design, synthesis and pharmacological evaluation of a novel PEGcRGD-conjugated irinotecan derivative as potential antitumor agent, European Journal of Medicinal Chemistry, 2018, 158, 82-90.
6.Wen-Bin Kuang#, Ri-Zhen Huang#, Jiao-Lan Qin, Xing Lu, Qi-Pin Qin, Bi-Qun Zou, Zhen-Feng Chen*, Hong Liang*, Ye Zhang*, Design, synthesis and pharmacological evaluation of new 3-(1Hbenzimidazol-2-yl)quinolin-2(1H)-one derivatives as potential antitumor agents, European Journal of Medicinal Chemistry, 2018, 157, 139-150.
7.Bi-Qun Zou#, Xing Lu#, Qi-Pin Qin, Yu-Xia Bai, Ye Zhang,* Meng Wang, Yan-Cheng Liu, Zhen-Feng Chen*, Hong Liang*, Three novel transition metal complexes of 6-methyl-2-oxo-quinoline-3-carbaldehyde thiosemicarbazone: synthesis, crystal structure, cytotoxicity, and mechanism of action[J], RSC Advances, 2017, 7, 17923-17933.
8.Ri-Zhen Huang, Shi-Xian Hua, Cai-Yi Wang, Ying-Ming Pan, Jian-Mei Qin, Zhan-Yu Ding, Ye Zhang*, Heng-Shan Wang*, 4-Methylumbelliferones analogues as anticancer agents: synthesis and in cell pharmacological studies[J], Anti-Cancer Agents in Medicinal Chemistry, 2017;17:576–589.
9.Ri-Zhen Huang#, Cai-Yi Wang#, Jian-Fei Li, Gui-Yang Yao, Ying-Ming Pan, Man-Yi Ye, Heng-Shan Wang*, Ye Zhang*, Synthesis, antiproliferative and apoptosis-inducing effects of novel asiatic acid derivatives containing a-aminophosphonates[J], RSC Advances, 2016, 6, 62890–62906.
10.Shi-Xian Hua, Ri-Zhen Huang, Man-Yi Ye, Ying-Ming Pan, Gui-Yang Yao, Ye Zhang*, Heng-Shan Wang*, Design, synthesis and in vitro evaluation of novel ursolic acid derivatives as potential anticancer agents, European Journal of Medicinal Chemistry, 2015, 95, 435-452.
11. Le Jin, Hong-En Qu, Xiao-Chao Huang, Ying-Ming Pan, Dong Liang, Zhen-Feng Chen, Heng-Shan Wang*, Ye Zhang*, Synthesis and biological evaluation of novel dehydroabietic acid derivatives conjugated with acyl-thiourea peptide moiety as antitumor agents, International Journal of Molecular Sciences, 2015, 16, 14571-14593.
12. zhen Ke,Aize Xie,Jianjiao Chen,Zhenyuan Zou,Lei Shen*,Yansong Dai* andDengfeng Zou*. Naturally available hypericin undergoing electron transferfor type I photodynamic and photothermal synergistic therapy. Biomaterials Science,2020, 8, 2481-2487. 13.Xujing Zhang, Aolin Zhang, Jingfei Feng, Jing Yi, Long Peng, Jianjiao Chen, Zhen Ke,Jie Yang*,Yansong DaiandDengfeng Zou*.A heavy atom free miconducting polymer with high singlet oxygen quantum yield for photodynamic and photothermal synergistic therapy. Materials and Design，2020，109263-109270.https://doi.org/10.1016/j.matdes.2020.109263.
14. JieYang, XinHe, ZhenKe, JianjiaoChen, ZhenyuanZou, BoWei,Dengfeng Zou*, JianhuaZou*. Two photoactive Ru (II) compounds based on tetrazole ligands for photodynamictherapy. Journal of Inorganic Biochemistry, https://doi.org/10.1016/j.jinorgbio.2020.111127
15.Xujing Zhang, Xiao Huang, Aize Xie, Xiaochuan Zhang,Jun Deng,Dengfeng Zou*,Jianhua Zou*. Boosting type I process of Ru(II) compounds by changing tetrazole ligand for enhanced photodynamic therapy against lung cancer. Journal of Inorganic Biochemistry ,https://doi.org/10.1016/j.jinorgbio.2020.111236.
16.Hongliang Xu, Xujing Zhang,Xinchen Li, Xiaochuan Zhang,Jun Deng,Dengfeng Zou*,Jie Yang*. Two Ru(II) compounds with aggregation induced emission as promising photosensitizers for photodynamic therapy. Journal of Inorganic Biochemistry，https://doi.org/10.1016/j.jinorgbio.2020.111233.
17. Huijuan Wen,Juan Ma,Jianjiao Chen, Dengfeng Zou*and Qiaoyun Li*.Heavy atom free 1,1,4,4-tetraphenylbuta-1,3-diene with aggregation induced emission forphotodynamic cancer therapy?.New Journal of Chemistry,2019, 43, 9183-9187.
18.Jian Shen,Zhen Ke,Jianjiao Chen,Zhenyuan Zou,Liguo Sun*andDengfeng Zou*.A heavy atom-free copolymer for light triggered photodynamic and photothermal therapy of human prostate cancer cells.New Journal of Chemistry, 2019，43（34）：13670-13674.
19.Gao Wen Yang,Xin Zhang, Guang Ming Li,Jie Yang,Lei Shen,Dian Yu Chen,a Qiao Yun Li*and Deng Feng Zou*. Photochemical property of a Ru(II) compound based on 3-(2-pyridyl)pyrazole and 2,2’-bipyridine for ablation of cancer cells.New Journal of Chemistry.,2018, 42, 5395-5402.
20. Min Yu#, Yong-Li Zhang#, Jin-Long Liu, Su-Juan wang, Gui-Jie Zhang*, Sesquineolignan and neolignan enantiomers fromTriadica sebifera, Bioorganic Chemistry. 2020, 103, 104147.
21. Gui-Jie Zhang#, Qi-Ming Pan#, Yong-Li Zhang, Hai-Bing Liao, Yan-Qiu Yang, Yue Hou, Dong Liang*, Coumarinolignoids and taraxerane triterpenoids fromSapium discolorand their inhibitory potential on microglial nitric oxide production, Journal of Natural Products, 2018, 81, 2251-2258.
22. Gui-Jie Zhang#, Feng Hu#, Huan Jiang, Lu-Mei Dai, Hai-Bing Liao, Ning Li, Heng-Shan Wang, Ying-Ming Pan*, Dong Liang*, Mappianines A-E, structurally diverse monoterpenoid indole alkaloids fromMappianthus iodoides,Phytochemistry, 2018, 145, 68-76.
23. Jin-Long Liu, Min Yu, Hai-Bing Liao, Ting Liu, Yan-Hui Tan, Dong Liang*, Gui-Jie Zhang*, Sesquiterpenes and diterpenes fromEuphorbia thymifolia,Fitoterapia, 2019, 139, 104408.
24. Yong-Li Zhang#, Qi-Min Pan, Hai-Bing Liao, Jiang-Ke Qin, Ning Li, Dong Liang*, Gui-Jie Zhang, Coumarinolignoids and lignanoids from the stems and leaves ofSapium discolor,Fitoterapia, 2019, 133, 17-22.
25. Mengqi Yan, Qin Luo, Xianli Zhou, Qinghu Mo, Caifeng Peng, Xiaoya Xian, Xiao Huang, Xinping Yang, Xu Chen & Chengqin Liang (2020): A new glucopyranoside from the leaves ofMicrosorium fortunei, Natural Product Research, DOI: 10.1080/14786419.2020.1731745
26. Qinghu Mo, Xianli Zhou*, Sixin Huang, Yun Zhou, JunfeiMou, QinLuo, Xiao Huang, Xinping Yang, Xu Chen, Chengqin Liang*. A new triterpenoidfrom the leaves ofRhodomyrtus tomentosa(Ait.) Hassk. Natural Product Research. 2019, DOI: 10. 1080/14786419.2019.1670176
27.Sixin Huang,JunfeiMou, Qin Luo,Qinghu Mo, Xianli Zhou*, Xiao Huang,Qing Xu, Xiangduan Tan, Xu Chen, Chengqin Liang*.Anti-Hepatitis B Virus Activity of Esculetin from Microsorium fortunei In Vitro and In Vivo. Molecules. 2019,24(19):3475.
28.Xianli Zhou, Sixin Huang, Pengcheng Wang, Qin Luo, Xiao Huang, QinXu, Jiangke Qin, Chengqin Liang*, Xu Chen*. A syringicacid derivative and two iridoidglycosides from the roots ofStachysgeo bombycis and their antioxidant properties.Natural Product Research, 2019, 35(3): 681-686
29. Xianli Zhou#, Qin Luo#, Sixin Huang, Pengcheng Wang, Qin Xu, Xiao Huang, Chengqin Liang*, Xu Chen*. New tetralone derivatives from the leaves of Cyclocarya paliurus.Journal of Asian Natural Products Research, 2019, 21(2): 157-164
30. Jingchen Wei#, Pengcheng Wang#, Xianli Zhou, Kun Tang, Qin Luo, Qin Xu, Xuejiao Chen, Chengqin Liang*, Xu Chen*. The caffeoylphenylethanoid glycosides from Lindernia ruellioides and their anti-HBV effects.Journal of Asian Natural Products Research, 2019, 20(8): 757-762
31. Mo-Han Huang,Bo Kong, Jie-Yun Meng, Yu-Bin Lv, Yan-Fen Peng, Yi-Ping Chen*, Xiang-Duan Tan*. Discovery of novel N-aryl pyrrothine derivatives as bacterial RNA polymerase inhibitors. [J]. Chemical Biology & Drug Design, 2020,96 (5): 1262–1271.
32. Xiangduan Tan, Mohan Huang, Siyun Nian, Yanfen Peng, Jianli Qin, Bo Kong?, Xiaoqun Duan?. Design, synthesis and biological evaluation of novel hybrids of N-aryl pyrrothine-base α-pyrone as bacterial RNA polymerase inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2020, 30: 127146.
33. Jieyun Meng, Bo Kong, Juan Wang, Xinping Yang, Yubin Lv, Liang Lyu, Zhimin Jiang, Xiangduan Tan*. Synthesis and biological evaluation of novel N-2,4-dimethoxyphenyl dithiolopyrrolone derivatives as bacterial RNA polymerase inhibitors[J]. Medicinal Chemistry Research, 2020, 29:1376–1386.
34.Si-Yun Nian, Guo-Ping Wang, Zheng-Li Jiang, Ying Xiao, Mo-Han Huang, Yi-Huan Zhou,Xiang-Duan Tan*. Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists[J]. Molecular Diversity, 2019, 23:19–33.
35. Bing Han(#); Yang Yang(#); Jiang Chen; Xingxing He; Nonghua Lv; Runwei Yan(*),PRSS23 knockdown inhibits gastric tumorigenesis through EIF2 signaling, Pharmacological Research, 2019, (142): 50-57.
36. Jinhui Shen(#); Yang Yang(#); Xiaoli Hou; Wenlei Zeng; Aimin Yu; Xiaowei Zhao; Xiangtai Meng(*),Darzens reaction of thioisatins and sulfonium salts:approach to the synthesis of thiochromenone derivatives with anticancer potency, Organic & Biomolecular Chemistry, 2018, (16): 3487-3494.
37. Jin Zeng(#); RuiJing Ma(#); Ling Wang; ShengNan Zhang; HongZhi Song; Yang Yang(*); Qin-Gang Tan(*), Chemical constituents from the leaves of Melia azedarach, Natural ProductResearch,2019, 33 (19): 2860-2863.
38. Enyi Gao(#); Shuwen Wu; Qing Xu; Yonglian Zeng; Ning Tan; Songqing He; Yang Yang(*); Jingchen Wei(*),Enterovirus type 71?immunized chicken egg yolk immunoglobulin has cross antiviral activity against coxsackievirus A16 in vitro, Experimental and Therapeutic Medicine, 2019, 18: 332-341.
39. Zu-Yu Mo, Toreshettahally R Swaroop, Wei Tong, Yu-Zhen Zhang, Hai-Tao Tang*, Ying-Ming Pan*, Hong-Bin Sun, Zhen-Feng Chen*. Electrochemical sulfonylation of thiols with sulfonyl hydrazides: a metal- and oxidant-free protocol for the synthesis of thiosulfonates. Green Chem., 2018, 20, 4428–4432.
40. Yu-Zhen Zhang?, Zu-Yu Mo?, Heng-Shan Wang, Xiao-An Wen, Hai-Tao Tang*, Ying-Ming Pan*. Electrochemically enabled chemoselective sulfonylation and hydrazination of indoles. Green Chem., 2019, 21, 3807–3811.
41. Zu-Yu Mo, Yu-Zhen Zhang, Guo-Bao Huang*, Xin-Yu Wang, Hai-Tao Tang*. Electrochemical Sulfonylation of Alkynes with Sulfonyl Hydrazides: A Metal- and Oxidant-free Protocol for the Synthesis of Alkynyl Sulfones. Adv. Synth. Catal., 2020, 362, 2160-2167.
42. Zu-Yu Mo, Xin-Yu Wang, Yu-Zhen Zhang, Li Yang*, Hai-Tao Tang, and Ying-Ming Pan*. Electrochemically enabled functionalization of indoles or anilines to synthesis of hexafluoroisopropoxy indole and anilinederivatives. Org. Biomol. Chem., 2020, 18, 3832-3837.
43. Hui Chen, Yunyun Yan, Niuniu Zhang, Zuyu Mo*, Yanli Xu*, and Yanyan Chen*. Visible-Light-Induced Cyclization/Aromatization of 2?Vinyloxy Arylalkynes: Synthesis of Thio-Substituted Dibenzofuran Derivatives. Org. Lett. 2020, DOI：10.1021/acs.orglett.0c03876.
44. Yong-Zhou Pan, Shi-Yan Cheng, Qian-Yu Li, Hai-Tao Tang, Ying-Ming Pan, Xiu-Jin Meng*, Zu-Yu Mo*, Electrocatalytic synthesis of gem-bisarylthio enamines and α-phenylthio ketones via a radical process under mild conditions. Synlett, 2020, DOI:10.1055/a-1335-7902.
45. Jia-Rong Zhang, Hao-Yang Liu, Tao Fan, Yan-Yan Chen,* and Yan-Li Xu* Synthesis of Indolo[2,1-a]isoquinolin-6(5H)-ones Derivatives via Fe(OTf)3-Promoted Tandem Selenylation/Cyclization of 2-Arylindoles, Adv. Synth. Catal. 2020, doi: 10.1002/adsc.202000983.
46. Xiu-Jie Zhou, Hao-Yang Liu, Zu-Yu Mo, Xian-Li Ma,* Yan-Yan Chen,* Hai-Tao Tang, YingMing Pan, Yan-Li Xu*, Visible Light-Promoted Selenylative Spirocyclization of Indolylynones toward the Formation of 3-Selenospiroindolenines Anticancer Agents,Chem. Asian J.2020,15, 1536-1539.
47. Qian Wang, Xian-Li Ma,* Yan-Yan Chen, Cai-Na Jiang,* and Yan-Li Xu*, Electrochemical Synthesis of 5-Selenouracil Derivatives by Selenylation of Uracils,Eur. J. Org. Chem.2020, 4384-4388.
48. Xian-Li Ma#, Qian Wang#, Xi-Yuan Feng, Zu-Yu Mo, Ying-Ming Pan,* Yan-Yan Chen, Mao Xin* and Yan-Li Xu*, Metal-Free Visible-Light Induced Cyclization/Substitution Cascade Reaction of Alkyne-tethered Cyclohexadienones and Diselenides: Access to 5-Hydroxy-3-selenyl-4a,8a-dihydro-2H-chromen-6(5H)-ones,Green Chem.2019,21, 3547-3551.
49. Hui Chen, Rui Ding, Haitao Tang, Yingming Pan, Yanli Xu* , Yanyan Chen* Simultaneous construction of C–Se and C–S bondsviathe visible-light mediated multicomponent cascade reaction of diselenides, alkynes, and SO2,Chem. Asian J.2019,14, 3264-3268.
50. Fei-hu Cui,Jing Chen,Zu-yu Mo,Shi-xia Su,Yan-yan Chen,Xian-li Ma,Hai-tao Tang,Heng-shan Wang,Ying-ming Pan,*and Yan-li Xu*, Copper-Catalyzed Decarboxylative/Click Cascade Reaction: Regioselective Assembly of 5-Selenotriazole Anticancer Agents,Org. Lett.2018,20, 925-929.
51. Fei-Hu Cui#, Jing Chen#, Shi-Xia Su, Yan-li Xu*, Heng-shan Wang and Ying-ming Pan*, Regioselective Synthesis of Selenide Ethers through a Decarboxylative Coupling Reaction,Adv. Synth. Catal.2017,359, 3950-3961.
52.Qing-hu Teng#, Yan-li Xu#, Ying Liang*, Heng-shan Wang, Ying-chun Wang and Ying-ming Pan*,Transition-Metal-Free Synthesis of 3-Alkynylpyrrole-2-CarboxylatesviaMichael Addition/Intramolecular Cyclodehydration,Adv. Synth. Catal.2016,358, 1897-1902.
53. Xiu Wang#, Fu-Hua Pang#, Lin Huang, Xin-Ping Yang, Xian-Li Ma, Cai-Na, Jiang, Fang-Yao Li *, Fu-Huo Lei, Synthesis and biological evaluation of novel dehydroabietic acid-oxazolidinone hybrids for antitumor properties. International journal of molecular sciences, 2018, 19(10), 3116.
54. Xiao-Ying Huang, Hui Chen, Zhong-Zhi Huang, Yan-Li Xu, Fang-Yao Li *, Xian-Li Ma *, Yan-Yan Chen *. Visible light-induced difunctionalization of alkynes: the synthesis of thiazoles and 1, 1-dibromo-1-en-3-ynes. Journal of Organic Chemistry, 2019, 84(23), 15283-15293.
55. Lin Huang#, Rong Huang#, Fu-Hua Pang, An-Ke Li, Guo-Bao Huang, Xiao-Qun Zhou*, Qian Li, Fang-Yao Li *, Xian-Li Ma. Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents. RSC Advances, 2020, 10, 18008-18015.
56. Fang-Yao Li, Lin Huang, Xiao-Qun Zhou, Qian Li, Xian-Li Ma, Wen-Gui Duan*，Xiu Wang, Synthesis and cytotoxicity evaluation of dehydroabietic acid derivatives bearing nitrate moiety, Chinese of Organic Chemistry, 2020, 40(9), 2845-2854.
57. Fang-Yao Li, Lin Huang, Qian Li, Xiu Wang, Xian-Li Ma , Cai-Na, Jiang, Wen-Gui Duan *, Lei, F H. Synthesis and antiproliferative evaluation of novel hybrids of dehydroabietic acid bearing 1, 2, 3-triazole moiety. Molecules, 2019, 24(22): 4191.
58. Fang-Yao Li, Xiu Wang, Wen-Gui Duan *, Gui-Sha Lin. Synthesis and in vitro anticancer activity of novel dehydroabietic acid-based acylhydrazones.Molecules, 2017, 22(7), 1087.
59. Yan Yao, Xiu-Jin Meng, Qing-Hu Teng*, Yan-Yan Chen*; Electrochemical Synthesis of Quinazolinones by the Metal-Free and Acceptor-Free Dehydrogenation of 2-Aminobenzamides.Synlett, 2020,31, 1795–1799.
60. Rui Ding; Hui Chen; Yan-Li Xu; Hai-Tao Tang; Yan-Yan Chen*; Ying-Ming
Pan*; Photoinduced Cascade Reaction of Tertiary Amines with Sulfonyl Azides: Synthesis of Amidine Derivatives,Advanced Synthesis & Catalysis, 2019,361, 3656-3660. (IF: 5.451)
61. Xiao-Ying Huang; Rui Ding; Zu-Yu Mo; Yan-Li Xu; Hai-Tao Tang; Heng-Shan
Wang*; Yan-Yan Chen*; Ying-Ming Pan*; Photocatalytic Construction of S-S and C-S Bonds Promoted by Acridinium Salt: An Unexpected Pathway To Synthesize 1,2,4- Dithiazoles,Organic Letters, 2018,20, 4819-4823. (IF: 6.555)
62.Wei Tong; Qian-Yu Li; Yan-Li Xu; Heng-Shan Wang; Yan-Yan Chen*; Ying-Ming Pan*; An Unexpected Domino Reaction of β-Keto Sulfones with Acetylene Ketones Promoted by Base: Facile Synthesis of 3(2H)-Furanones and Sulfonylbenzenes,Advanced Synthesis & Catalysis, 2017,359, 4025-4035. (IF: 5.451).
63.Wan-Yun Huanga*, Xiao-RongZhanga, Liang Lyub*, Shu-QinWanga, Xiao-Ting Zhanga, Pyridazino[1,6-b]quinazolinones as new anticancer scaffold: Synthesis, DNA intercalation, topoisomerase I inhibition and antitumor evaluationin vitroandin vivo.Bioorganic Chemistry 2020, 99, 103814-103825.
64.Ji Li a,1, Wan-Yun Huang b,c,1, Shao-Song Qian a, Qing-Yun Li a, Hai-Liang Zhu a,*. Two novel 2D waves copper(II) coordination polymer with the quinolone antimicrobial drugs ciprofloxacin: Synthesis, structure and biological evaluation. Inorganica Chimica Acta. 2015, 435, 16-24.
65. Xin-Wei Wei a,1, Jing-Mei Yuan a,1, Wan-Yun Huang b, Nan-Ying Chen a, Xiao-Juan Lia,Cheng-Xue Pan a,*, Dong-Liang Mo a,**, Gui-Fa Su a,** 2-Styryl-4-amino- quinazoline derivatives as potent DNA-cleavage, p53-activation and in vivo effective anticancer agents. European Journal of Medicinal Chemistry. 2020, 186, 111851-111867.
66. Ting Zhou, Wei Zhang, Dongliang Cheng, Xin Tang, Jianfang Feng*, Wei Wu*. Preparation, characterization, and in vivo evaluation of NK4-conjugated hydroxycamptothecin-loaded liposomes. International Journal of Nanomedicine. 2020, 15: 2277-2286.
67. Tan Yang, Qian Zhang, Tiane Chen, Wei Wu*, Xin Tang*, Ge Wang*, Jianfang Feng*, Wei Zhang*. Facile potentiometric sensing of gallic acid in edible plants based on molecularly imprinted polymer. Journal of Food Science. 2020, 85(8): 2622-2628.
68. Dandan Wang, Yuting Wang, Guangchao Zhao, Jie Zhuang*, Wei Wu*. Improving systemic circulation of paclitaxel nanocrystals by surface hybridation of DSPE-PEG2000. Colloids and Surfaces B: Biointerfaces, 2019, 182, 110337.
69. Ting Zhou, Xin Tang, Wei Zhang, Jianfang Feng, Wei Wu*. Preparation and in vitro and in vivo evaluations of 10-hydroxycamptothecin liposomes modified with stearyl glycyrrhetinate. Drug Delivery, 2019, 26(1): 673-679.
70. Jie Zhuang, Dandan Wang, Dong Li, Yinqian Yang, Yi Lu, Wei Wu, Wei Wu*, Jianping Qi*. The influence of nanoparticle shape on bilateral exocytosis from Caco-2 cells. Chinese Chemical Letters, 2018, 29(12): 1815-1818.
71. Ri-Zhen Huang#, Xiao-Teng Jing#, Xiao-Chao Huang, Ying-Ming Pan, Yi-Lin Fang, Gui-Bin Liang, Zhi-Xin Liao, Heng-Shan Wang*, Zhen-Feng Chen*, Ye Zhang*, Bifunctional naphthoquinone aromatic amide-oxime derivatives exert combined immunotherapeutic and antitumor effects through simultaneous targeting of indoleamine-2,3-dioxygenase and signal transducer and activator of transcription 3, Journal of Medicinal Chemistry, 2020, 63(4), 1544?1563.
72. Xiaochao Huang#,*, Meng Wang#, Qinghong You, Jing Kong, Haijiang Zhang, Chunhao Yu, Yanming Wang, Hengshan Wang*, Rizhen Huang*. Synthesis, mechanisms of action, and toxicity of novel aminophosphonates derivatives conjugated irinotecan in vitro and in vivo as potent antitumor agents. European Journal of Medicinal Chemistry, 2020, 189, 112067.
73. Israa Assani, Ying Du, Chun-Gu Wang, Lei Chen, Pei-Lei Hou, Shi-Feng Zhao, Yan Feng, Ling-Fei Liu, Bo Sun, Yan Li, Zhi-Xin Liao*, Ri-Zhen Huang*. Anti-proliferative effects of diterpenoids from Sagittaria trifolia L. tubers on colon cancer cells by targeting the NF-κB pathway, Food & Function, 2020, 11, 7717-7726.
74. Ri-Zhen Huang#, Gui-Bin Liang#, Mei-Shan Li, Yi-Lin Fang, Shi-Feng Zhao, Mei-Mei Zhou, Zhi-Xin Liao*, Jing Sun* and Heng-Shan Wang*. Synthesis and discovery of asiatic acid based 1,2,3-triazole derivatives as antitumor agents blocking NF-κB activation and cell migration, Med. Chem. Commun., 2019, 10, 584–597.
75. Huang Ri-Zhen#, Huang Xiao-Chao#, Zhang Bin, Jia Hai-Yang, Liao Zhi-Xin*, Wang Heng-Shan*, 16-O-caffeoyl-16-hydroxylhexadecanoic acid, a medicinal plant-derived phenylpropanoid, induces apoptosis in human hepatocarcinoma cells through ROS-dependent endoplasmic reticulum stress, Phytomedicine, 2018, 41, 33–44.
76. Xiaochao Huang#, Rizhen Huang#, Zhimei Wang, Lingxue Li, Shaohua Gou*, Zhixin Liao, Hengshan Wang*, Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerization exhibited selective inhibition in human cancer cells. European Journal of Medicinal Chemistry, 2018, 146, 435-450.
77. Wen-Bin Kuang#, Ri-Zhen Huang#, Jiao-Lan Qin, Xing Lu, Qi-Pin Qin, Bi-Qun Zou, Zhen-Feng Chen*; Hong Liang*, Ye Zhang*, Design, synthesis and pharmacological evaluation of new 3-(1H-benzimidazol-2-yl)quinolin-2(1H)-one derivatives as potential antitumor agents, European Journal of Medicinal Chemistry, 2018, 157, 139?150.
78. Wei Jiang#, Ri-Zhen Huang#, Jing Zhang, Tong Guo, Meng-Ting Zhang, Xiao-Chao Huang, Bin Zhang, Zhi-Xin Liao*, Jing Sun*, Heng-Shan Wang*, Discovery of antitumor ursolic acid long-chain diamine derivatives as potent inhibitors of NF-κB. Bioorganic Chemistry, 2018, 79, 265–276.
79. Ri-Zhen Huang#, Gui-Bin Liang#, Xiao-Chao Huang, Bin Zhang, Mei-Mei Zhou, Zhi-Xin Liao*, Heng-Shan Wang*. Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation, European Journal of Medicinal Chemistry, 2017, 138, 979-992.
80. Jian-Mei Qin#, Ri-Zhen Huang#, Gui-Yang Yao, Zhi-Xin Liao, Ying-Ming Pan*, Heng-Shan Wang*, Terminal functionalized thiourea-containing dipeptides as multidrug-resistance reversers that target 20S proteasome and cell proliferation. European Journal of Medicinal Chemistry, 2017, 126, 259-269.
81. Xiaochao Huang#, Rizhen Huang#, Lingxue Li, Shaohua Gou*, Hengshan Wang*, Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents. European Journal of Medicinal Chemistry. 2017, 132, 11-25.
82. Gui-Bin Liang1, Jian-Hua Wei*1, Hong Jiang, Ri-Zhen Huang, Jiang-Ting Qin, Hui-Ling Wang, Heng-Shang Wang, Ye Zhang*, Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA,European Journal of Medicinal Chemistry,2020, DOI: 10.1016/j.ejmech.2020.112951.
83. Mao Xin1, Jian-Hua Wei1, Chen-Hui Yang, Gui-Bin Liang, Dan Su, Xian-Li Ma*, Ye Zhang*, Design, synthesis and biological evaluation of 3-nitro- 1,8-naphthalimides as potential antitumor agents,Bioorganic &Medicinal Chemistry Letters,2020, 30:1-6.
84. Jian-Hua Wei, Anna K. Renfrew*, Photolabile ruthenium complexes to cage and release a highly cytotoxic anticancer agent,Journal of Inorganic Biochemistry,2017, 22: 146-153.
85. Hazel Chan1, Joy B. Ghrayche1, Jian-Hua Wei1, and Anna K. Renfrew*, Photolabile ruthenium (II)-purine complexes: Phototoxicity, DNA binding, and light-triggered drug release,European Journal of Inorganic Chemistry，2017, 44: 1679-1680.
86. Yilin Fang, Zhilin Wu, Mengwu Xiao, Li Wei, Kangming Li, Yuting Tang, Jiao Ye, Jiannan Xiang, Aixi Hu, Design, synthesis, and evaluation of new 2-oxoquinoline arylaminothiazole derivatives as potential anticancer agents[J]. Bioorganic Chemistry, doi.org/10.1016/j.bioorg.2020.104469.
87.Dong-Kai Wang,?a Yi-Lin Fang,?b,c Jian Zhang,a Yu-Tao Guan,a Xun-Jie Huang,a Jianfeng Zhang,*a Qiang Li*b and Wen-Ting Wei*a, Radical cyclizations of enynes/dienes with alcohols in water using a green oxidant[J]. Org. Biomol. Chem., 2020, 18, 8491–8495.
88.Ming Cao,§ Yi-Lin Fang,§ Ying-Chun Wang,* Xiao-Juan Xu, Zhi-Wei Xi, and Shi Tang*, Ce(OTf)3?Catalyzed Multicomponent Reaction of Alkynyl Carboxylic Acids, tert-Butyl Isocyanide, and Azides for the Assembly of Triazole?Oxazole Derivatives[J]. ACS Comb. Sci. 2020, 22, 5, 268-273.
89.Yi-Ning Wang, Qiang Li, Yi-Lin Fang, Le-Han Gao, Si-Zhe Song, Youren Dong, and Wen-Ting Wei*. Potassium-Persulfate-Promoted Regioselective Azidation/Cyclization of 1,6-Enynes. Asian J. Org. Chem. 2019, 8, 832-835.
90.Yilin Fang, Mengwu Xiao, Aixi Hu, Jiao Ye, Wenwen Lian, Ailin Liu, Design, Synthesis, and Evaluation of 3-((4-(t-Butyl)-2-(2-benzylidenehydrazinyl) thiazol-5-yl)methyl)quinolin-2(1H)-ones as Neuraminidase Inhibitors, Chin. J. Chem., 2016, 34: 403-411.
91.Yilin Fang, Zhilin Wu, Mengwu Xiao, Yuting Tang, Kangming Li, Jiao Ye, Jiannan Xiang; Aixi Hu, One-Pot Three-Component Synthesis of Novel Diethyl((2-oxo-1,2- dihydroquinolin-3-yl) (arylamino) methyl)phosphonate asPotential Anticancer Agents , Int. J. Mol. Sci., 2016, 17: 653-668.
92.Zhilin Wu, Yilin Fang, Yuting Tang, Mengwu Xiao, Jiao Ye, Guoxi Li, Aixi Hu, Synthesis and antitumor evaluation of 5-(benzo-[d][1,3]dioxol-5-ylmethyl)-4 -(tert-butyl)-N-arylthiazol-2-amines, Med. Chem. Commun., 2016, 7: 1768-1774.
93.Pei S, Liu L, Zhong Z, Wang H, Lin S, Shang J. Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine. Sci Rep. 2016 Oct 5;6:33822. IF:3.998
94.Wang YX, Xue DT, Liu M, Zhou ZM, Shang J. A novel arctigenin-containing latex glove prevents latex allergy by inhibiting type I/IV allergic reactions. Chin J Nat Med. 2016 Mar;14(3):185-95. IF:2.014
95.Wu H, Feng J, Lv W, Huang Q, Fu M, Cai M, He Q, Shang J. Developmental Neurotoxic Effects of Percutaneous Drug Delivery: Behavior and Neurochemical Studies in C57BL/6 Mice. PLoS One. 2016 Sep 8;11(9):e0162570. IF:2.74
96.Pei S, Liu L, Zhong Z, Wang H, Lin S, Shang J. Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine. Sci Rep. 2016 Oct 5;6:33822. IF:3.998
97.Wu H, Liu Q, Kalavagunta PK, Huang Q, Lv W, An X, Chen H, Wang T, Heriniaina RM, Qiao T, Shang J. Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice. Metab Brain Dis. 2018 Feb;33(1):177-190. IF：2.726
98.Liao S, Lv J, Zhou J, Kalavagunta PK, Shang J. Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice. Exp Dermatol. 2017 Nov;26(11):1083-1090. IF：3.368
99.Wang H, Zhou J, Liu QZ, Wang LL, Shang J. Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice. Sci Rep. 2017 May 24;7(1):2335.IF：3.998
100.Liu M, Chen X, Ma J, Hassan W, Wu H, Ling J, Shang J. β-Elemene attenuates atherosclerosis in apolipoprotein E-deficient mice via restoring NO levels and alleviating oxidative stress. Biomed Pharmacother. 2017 Nov;95:1789-1798.IF：4.545
101.Wang L, Wu S, Cai M, Ma J, Li S, Li M, Xu Y, Wei L, Shang J. Comprehensive Study of Multiple Stages Progressing to Nonalcoholic Steatohepatitis with Subsequent Fibrosis in SD Rats. Int J Mol Sci. 2017 Aug 18;18(8):1681.IF：4.556
102.Dong J, An X, Zhong H, Wang Y, Shang J, Zhou J. Interleukin-22 participates in the inflammatory process of vitiligo. Oncotarget. 2017 Nov 24;8(65):109161-109174. IF：5.168
103.Xia Z, Wei L, Du Y, Wang L, Han J, He Q, Chen H, Zou X, Wu H, Shang J. Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells. Chem Pharm Bull (Tokyo). 2018 ;66(8):818-821. IF:1.416
104.Wang Q, Wu H, Zhou J, Pei S, Li J, Cai Y, Shang J. Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains. PLoS One. 2018 Oct 24;13(10):e0202955. IF：2.74
105.Li M, Ma J, Ahmad O, Cao Y, Wang B, He Q, Li J, Yin H, Zhang Y, He J, Shang J. Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model. J Pharmacol Sci. 2018 Dec;138(4):257-262. IF：2.835
106.Liu M, Jiang S, Ma Y, Ma J, Hassan W, Shang J. Peripheral-blood gene expression profiling studies for coronary artery disease and its severity in Xinjiang population in China. Lipids Health Dis. 2018 Jul 18;17(1):154.IF：2.906
107.Zhou LL, Chen HJ, He QQ, Li C, Wei LX, Shang J. Evaluation of hepatotoxicity potential of a potent traditional Tibetan medicine Zuotai. J Ethnopharmacol. 2019 Apr 24;234:112-118. IF：3.69
108.Zhong H, Daoud A, Han J, An X, Qiao C, Duan L, Wang Y, Chen Z, Zhou J, Shang J. A Small β-Carboline Derivative "B-9-3" Modulates TGF-β Signaling Pathway Causing Tumor Regression in Vivo. Front Pharmacol. 2018 Jul 19;9:788.IF：4.225
109.Ma J, Li M, Kalavagunta PK, Li J, He Q, Zhang Y, Ahmad O, Yin H, Wang T, Shang J. Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models. Biomed Pharmacother. 2018 Aug;104:679-685.IF：4.545
110.Qin G, Ma J, Huang Q, Yin H, Han J, Li M, Deng Y, Wang B, Hassan W, Shang J. Isoquercetin Improves Hepatic Lipid Accumulation by Activating AMPK Pathway and Suppressing TGF-β Signaling on an HFD-Induced Nonalcoholic Fatty Liver Disease Rat Model. Int J Mol Sci. 2018 Dec 19;19(12):4126.IF：4.556
111.Wu H, Zhao Y, Huang Q, Cai M, Pan Q, Fu M, An X, Xia Z, Liu M, Jin Y, He L, Shang J. NK1R/5-HT1AR interaction is related to the regulation of melanogenesis. FASEB J. 2018 Jun;32(6):3193-3214.IF:4.966
112.Zhou J , An X , Dong J , Wang Y, Zhong H, Duan L, Ling J, Ping F, Shang J*. IL-17 induces cellular stress microenvironment of melanocytes to promote autophagic cell apoptosis in vitiligo[J]. Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology, 2018, 32(9):fj201701242RR.
113.Zou X, Liu Q, Guo S, Zhu J, Han J, Xia Z, Du Y, Wei L, Shang J. A Novel Zebrafish Larvae Hypoxia/Reoxygenation Model for Assessing Myocardial Ischemia/Reperfusion Injury. Zebrafish. 2019 Oct;16(5):434-442.IF：1.642
114.Yin H, Ma J, Han J, Li M, Shang J. Pharmacokinetic comparison of quercetin, isoquercitrin, and quercetin-3-O-β-D-glucuronide in rats by HPLC-MS. PeerJ. 2019 Mar 26;7:e6665.IF：2.379
115.Pan Q, Liu Q, Wan R, Kalavagunta PK, Liu L, Lv W, Qiao T, Shang J, Wu H. Selective inhibition of intestinal 5-HT improves neurobehavioral abnormalities caused by high-fat diet mice. Metab Brain Dis. 2019 Jun;34(3):747-761.IF：2.726
116.Wang Q, Wang Y, Pang S, Zhou J, Cai J, Shang J. Alcohol extract from Vernonia anthelmintica willd (L.) seed counteracts stress-induced murine hair follicle growth inhibition. BMC Complement Altern Med. 2019 Dec 17;19(1):372. IF：2.833
117.Cai M, Zhou L, Liao J, Huang Q, Xia Z, Shang J. IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro. J Pharmacol Sci. 2019 Sep;141(1):1-8. IF:2.835
118.Xia Z, Zhang Y, Li C, Xu Y, Dong J, Wang L, He Q, Zou X, Wu H, Han J, Cai M, Du Y, Wei L, Shang J. Traditional Tibetan medicine Anzhijinhua San attenuates ovalbumin-induced diarrhea by regulating the serotonin signaling system in mice. J Ethnopharmacol. 2019 May 23;236:484-494. IF:3.69
119.He Q, Ma J, Kalavagunta PK, Zhou L, Zhu J, Dong J, Ahmad O, Du Y, Wei L, Shang J. HgS Inhibits Oxidative Stress Caused by Hypoxia through Regulation of 5-HT Metabolism Pathway. Int J Mol Sci. 2019 Mar 18;20(6):1364. IF:4.556
120.Xu Y, Han J, Dong J, Fan X, Cai Y, Li J, Wang T, Zhou J, Shang J. Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development. Int J Mol Sci. 2019 Mar 11;20(5):1220.IF:4.556
121.Liu L, Fu M, Pei S, Zhou L, Shang J. R-Fluoxetine Increases Melanin Synthesis Through a 5-HT1A/2A Receptor and p38 MAPK Signaling Pathways. Int J Mol Sci. 2018 Dec 25;20(1):80.IF:4.556
122. Zhong H, Zhou J, An XH, Hua YR, Lai YF, Zhang R, Ahmad O, Zhang Y, Shang J. Natural product-based design, synthesis and biological evaluation of 2',3,4,4'-tetrahydrochalcone analogues as antivitiligo agents. Bioorg Chem. 2019 Jun;87:523-533.IF:4.831
123.Ma J, Yin H, Li M, Deng Y, Ahmad O, Qin G, He Q, Li J, Gao K, Zhu J, Wang B, Wu S, Wang T, Shang J. A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs. Int J Biol Sci. 2019 Mar 10;15(5):973-983.IF:4.858
124.Song Z, Cai Y, Lao X, Wang X, Lin X, Cui Y, Kalavagunta PK, Liao J, Jin L, Shang J, Li J. Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome. Microbiome. 2019 Jan 23;7(1):9.IF:11.607
125.Zhou LL, Chen HJ, He QQ, Li C, Wei LX, Shang J. Evaluation of hepatotoxicity potential of a potent traditional Tibetan medicine Zuotai. J Ethnopharmacol. 2019 Apr 24;234:112-118.IF：3.69
126.Ahmad O, Wang B, Ma K, Deng Y, Li M, Yang L, Yang Y, Zhao J, Cheng L, Zhou Q, Shang J. Lipid Modulating Anti-oxidant Stress Activity of Gastrodin on Nonalcoholic Fatty Liver Disease Larval Zebrafish Model. Int J Mol Sci. 2019 Apr 23;20(8):1984.IF：4.556
127.Wu H, Lv W, Pan Q, Kalavagunta PK, Liu Q, Qin G, Cai M, Zhou L, Wang T, Xia Z, Shang J. Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation. J Affect Disord. 2019 Jan 15;243:83-95. IF：3.892
128.Liu L, Zhong M, Dong J, Chen M, Shang J, Yue Y. 5-Hydroxytryptamine (5-HT) Positively Regulates Pigmentation via Inducing Melanoblast Specification and Melanin Synthesis in Zebrafish Embryos. Biomolecules. 2020 Sep 19;10(9):1344. IF：4.082
129.Wang L, Fan X, Han J, Cai M, Wang X, Wang Y, Shang J. Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis via the Liver HTR2A/PPARγ2 Pathway. Front Pharmacol. 2020 May 14;11:553. IF：4.225
130.Zhong H, Lai Y, Zhang R, Daoud A, Feng Q, Zhou J, Shang J. Low Dose Cyclophosphamide Modulates Tumor Microenvironment by TGF-β Signaling Pathway. Int J Mol Sci. 2020 Jan 31;21(3):957. IF：4.556
131.Fan X, Han J, Zhu L, Chen Z, Li J, Gu Y, Wang F, Wang T, Yue Y, Shang J. Protective Activities of Dendrobium huoshanense C. Z. Tang et S. J. Cheng Polysaccharide against High-Cholesterol Diet-Induced Atherosclerosis in Zebrafish. Oxid Med Cell Longev. 2020 Jul 8;2020:8365056. IF：5.076
132. Fu Can#; Liu Xiaxia#; Li Xuezhi#; Huo Panfei; Ge Jingjing; Hou Yanfei; Yang Wenwen; Zhang Jingxia; Zhang Limin; Zhao Dazhong; Ma Changle*; Liu Jian*. BRF negatively regulates thermotolerance defect of fes1a in Arabidopsis. Frontiers in Plant Science, 2020, 11: 171.
133. Fu Can#; Hou Yanfei#; Ge Jingjing; Zhang Limin; Liu Xiaxia; Huo Panfei; Liu Jian*. Increased fes1a thermotolerance is induced by BAG6 knockout. Plant Molecular Biology, 2019, 100(1-2): 73-82.
134. Fu Can; Liu Xiaxia; Yang Wenwen; Zhao Chunmei; Liu Jian*. Enhanced salt tolerance in tomato plants constitutively expressing heat-shock protein in the endoplasmic reticulum. Genetics & Molecular Research. 2016, 15(2): gmr15028301.
135. Zhang kaiyue; Yang Wenwen; Yu Hongbin; Fu Can; Liu Xiaxia; Liu Jian*. Double mutation of BRF1 and BRF2 leads to sterility in Arabidopsis thaliana. Biochemical and Biophysical Research Communications, 2019, 516: 969-975.
136. Liu Xiaxia; Fu Can; Yang Wenwen; Zhang Quan; Fan Hai; Liu Jian*. The involvement of TsFtsH8 in Thellungiella salsuginea tolerance to cold and high light stresses. Acta Physiologiae Plantarum, 2016, 38(3): 62.
137. Jintao Gao, Fangru Chen, Huanan Fang, Jing Mi,Qi Qi, Mengjuan Yang. Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice[J]. Biological Research,2020,53(1).
138. Jintao Gao, Junfan Guo, Yuejuan Nong, Wenfei Mo, Huanan Fang, Jing Mi, Qi Qi, Mengjuan Yang, 18beta-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice. BMC pharmacology & toxicology 2020, 21(1):41.
139. Jintao Gao, Fangru Chen, Mingchun Hua, Junfan Guo, Yuejuan Nong, Qinyan Tang, Fengxia Zhong, Linxiu Qin, Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes. Biological research 2018, 51(1):30.
140.Shiwei Zhou#, Honghao Yu#, Xiaoe Zhao, Bei Cai, Qiang Ding, Yu Huang, xin Li, Yan Li, Yiyuan Niu, Anmin Lei, Qifang Kou, Xingxu Huang, Bjorn Petersen, Baohua Ma, Yulin Chen and Xiaolong Wang*. Generation of gene-edited sheep with a defined Booroola fecundity gene (FecBB) mutation in bone morphogenetic protein receptor type 1B (BMPR1B) via clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9. Reproduction. 2018, Fertility and Development. https://doi.org/10.1071/RD18086.
141.Yu Honghao#, Long Weihu#, Zhang Xuezeng#, Xu Kaixiang, Guo Jianxiong, Zhao Heng, Li Honghui, Qing Yubo, Pan Weirong, Jia Baoyu, Zhao Hong-Ye, Huang, Xingxu, Wei Hong-Jiang. (2018) Generation of GHR-modified pigs as Laron syndrome models via dual-sgRNAs/Cas9 system and somatic cell nuclear transfer. Journal of Translational Medicine 16, 41.
142.Yu HH#, Zhao H#, Qing YB, Pan WR, Jia BY, Zhao HY, Huang XX, Wei HJ. Porcine Zygote Injection with Cas9/sgRNA Results in DMD-Modified Pig with Muscle Dystrophy. Int J Mol Sci. 2016, 17(10). pii: E1668.
143. Wang X#, Niu Y#, Zhou J#, Yu H#, Kou Q, Lei A, Zhao X, Yan H, Cai B, Shen Q, Zhou S, Zhu H, Zhou G, Niu W, Hua J, Jiang Y, Huang X, Ma B, Chen Y. Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep.Sci Rep. 2016, 26, 6: 32271.
144.Yong Li#, Yu-feng Yao#, Jia Li#, Qiu-yun Chen#, Lu Zhang, Qing-kenneth Wang*. Losartan protects against myocardial ischemia/reperfusion injury via vascular integrity perservation. FASEB Journal, 2019; 33:8555-8564.
145. Yu-feng Yao#,Yong Li#, Chang-qin Hu, Qi-xue Song,Wen Xie, Cheng-qi Xu, Qiu-yun Chen, Qing-kenneth Wang*. Angiogenic Factor AGGF1 Primed Endothelial Progenitor Cells Repair Vascular Defect in Diabetic Mice. Diabetes, 2019; 68:1635-1648.
146. Yu-feng Yao#, Yong Li#, Xiao-fei Zeng, Zheng Ye, Xia Li*, Lu Zhang *.Losartan alleviates renal fibrosis and inhibits endothelial-to-mesenchymal transition (EMT) under high-fat diet-induced hyperglycemia. Front Pharmacol. 2018; 29(9):1213.
147. Teng Zhang #, Yufeng Yao #, Jing-jing Wang #, Yong Li #, Ping He; Vinay Pasupuleti, Zheng-kun Hu, Xin-zhen Jia, Qi-xue Song, Xiao-li Tian, Chang-qing Hu, Qiu-yun Chen*, Qingkenneth Wang*. Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin, Human Molecular Genetics, 2016; 25(23): 5094-5110.
148. Shengshi Jiang1, Honghui Ni1, Fen Liu, Shanshan Gu, Ping Yu*, Yi Gou*, Binuclear Schiff base copper(II) complexes: Syntheses, crystal structures, HSA interaction and anti-cancer properties, Inorganica Chimica Acta, 2020, 499: 119186.
149. ShanShan Gu1, Ping Yu1, JiaNan Hu, Yani Liu, ZuoWen Li, Yong Qian, Ya Wang, Yi Gou*, Feng Yang*, Mitochondria-localizing N-heterocyclic thiosemicarbazone copper complexes with good cytotoxicity and high antimetastatic activity, European Journal of Medicinal Chemistry, 2019, 164: 654-664.
150. QingYou Mo1, JunGang Deng1, Yani Liu, GuiDong Huang, ZuoWen Li, Ping Yu, Yi Gou*, Feng Yang*, Mixed-ligand Cu(II) hydrazone complexes designed to enhance anticancer activity, European Journal of Medicinal Chemistry, 2018, 156: 368-380.
151. JunGang Deng1, Gaoxing Su1, Peng Chen1, Yunpeng Du, Yi Gou*, Yani Liu*, Evaluation of DNA binding and DNA cleavage of nickel(II) complexes with tridentate a-N-heterocyclic thiosemicarbazones ligands, Inorganica Chimica Acta, 2018, 471: 194-202.
152. JunGang Deng, Tao Li, Gaoxing Su, Qi-Pin Qin, Yani Liu*, Yi Gou*, Co(III) complexes based on α-N-heterocyclic thiosemicarbazone ligands: DNA binding, DNA cleavage, and topoisomerase I/II inhibitory activity studies, Journal of Molecular Structure, 2018, 1167: 33-43.
153. Yi Gou, Dandan Miao, Min Zhou, Lijuan Wang, Hongyu Zhou*, Gaoxing Su*, Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics, Front in Pharmacology, 2018, 9: 421.
154. Jun Wang1, Yi Gou1 (Co-firstauthors), Zhenglei Zhang, Ping Yu, Jinxu Qi, Qipin Qin, Hongbin Sun, Xiaoyang Wu, Hong Liang*, Feng Yang*, Developing an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin, Molecular Pharmaceutics, 2018, 15(6):2180-2193.
155. Yi Gou1 (Co-firstauthors), Zhenlei Zhang1, Dongyang Li1, Lei Zhao, Meiling Cai, Zhewen Sun, Yongping Li, Yao Zhang, Hamid Khan, Hongbing Sun, Tao Wang, Hong Liang*, Feng Yang*, HSA-based multi-target combination therapy: regulating drugs' release from HSA and overcoming single drug resistance in a breast cancer model, Drug Delivery, 2018, 25(1): 321-329.
156. Yi Gou, Yao Zhang, Zhenlei Zhang, Jun Wang, Zuping Zhou, Hong Liang*, Feng Yang*, Design of an anticancer copper(II) prodrug based on the Lys199 residue of the active targeting human serum albumin nanoparticle carrier, Molecular Pharmaceutics, 2017, 14(6):1861-1873.
157. Yi Gou*, Jinlong Li, Boyi Fan, Bohui Xu, Min Zhou, Feng Yang*, Structure and biological properties of mixed-ligand Cu(II) Schiff base complexes as potential anticancer agents, European Journal of Medicinal Chemistry, 2017, 134: 207-217.
158. Yi Gou1 (Co-firstauthors), Yao Zhang1, Jinxu Qi, Shifang Chen, Zuping Zhou, Xiaoyang Wu, Hong Liang*, Feng Yang*, Developing an anticancer copper(II) pro-drug based on the nature of cancer cell and human serum albumin carrier IIA subdomain: Mouse model of breast cancer, Oncotarget, 2016, 7(41): 67004-67019.
159. Yi Gou, Jun Wang, Shifang Chen, Zhan Zhang, Yao Zhang, Wei Zhang, Feng Yang*, α-N-heterocyclic thiosemicarbazone Fe(III) complex: Characterization of its antitumor activity and identification of anticancer mechanism, European Journal of Medicinal Chemistry, 2016, 123: 354-364.
160. Zhenlei Zhang1, Yi Gou1 (Co-firstauthors), Jun Wang#, Kun Yang, Jinxu Qi, Zuping Zhou, Shichu Liang, Hong Liang*, Feng Yang*, Four copper(II) compounds synthesized by anion regulation: Structure, anticancer function and anticancer mechanism, European Journal of Medicinal Chemistry, 2016, 121: 399-409.
161. JunGang Deng1, Yi Gou1 (Co-firstauthors), Wei Chen, Xiang Fu, Hang Deng*, The Cu/ligand stoichiometry effect on the coordination behavior of aroyl hydrazone with copper(II): Structure, anticancer activity and anticancer mechanism, Bioorganic & Medicinal Chemistry, 2016, 24(10): 2190-2198.
162. Yi Gou, Feng Yang, Hong Liang*, Designing prodrugs based on special residues of human serum albumin, Current Topics in Medicinal Chemistry, 2016, 16: 996-1008.
163.Ming-Xiong Tan, Zhen-Feng Wang, Qi-Pin Qin, Bi-Qun Zou*, Hong Liang*,Complexes of oxoplatin with rhein and ferulic acid ligands as platinum( IV ) prodrugs with high anti-tumor activity[J]Dalton Trans., 2020, 49, 1613–1619
164. Bi-Qun Zou, Xiao-Ling Huang , Qi-Pin Qin , Zhen-Feng Wang , Xue-Yu Wu , Ming-Xiong Tan , Hong Liang* ,Transition metal complexes with 6,7-dichloro-5,8-quinolinedione as mitochondria-targeted anticancer agents[J] Polyhedron , 181 (2020) 114482
165. Qi-Pin Qin *, 1, Bi-Qun Zou 1, Zhen-Feng Wang , Xiao-Ling Huang , Ye Zhang,Ming-Xiong Tan , Shu-Long Wang , Hong Liang** , High in vitro and in vivo antitumor activities of luminecent platinum(II) complexes with jatrorrhizine derivatives [J] European Journal of Medicinal Chemistry 183 (2019) 111727
166. Li-Qin Qin, Bi-Qun Zou, Qi-Pin Qin, Zhen-Feng Wang, Lin Yang, Ming-Xiong Tan, Chun-Jie Liang and Hong Liang Highly cytotoxic, cyclometalated iridium(III)-5-fluoro-8-quinolinol complexes as cancer cellmitochondriotropic agents[J].New J. Chem., 2020, 44, 7832--7837
167. Yan Yang, Yi-Dong Bin, Qi-Pin Qin, Xu-Jian Luo, Bi-Qun Zou , and Hua-Xin Zhang Novel Quinoline-based Ir(III) Complexes Exhibit High Antitumor Activity in Vitro and in Vivo[J] ACS Med. Chem. Lett. 2019, 10, 1614?1619
168.Qi-Pin Qin, Ting Meng, Min-Xiong Tan, Yan-Cheng Liu, Xu-Jian Luo, Bi-Qun Zou*, Hong Liang. Synthesis, crystal structure and biological evaluation of a new dasatinib copper (II) complex as telomerase inhibitor[J]. European journal of medicinal chemistry, 2018, 143, 1597-1603.
169.Qi-Pin Qin, Ting Meng, Min-Xiong Tan, Yan-Cheng Liu, Xu-Jian Luo, Bi-Qun Zou*, Hong Liang. Synthesis and in vitro biological evaluation of three 4′-(4-methoxyphenyl)-2, 2′: 6′, 2 ″-terpyridine iridium (III) complexes as new telomerase inhibitors[J]. European journal of medicinal chemistry, 2018, 143, 1387-1395.
170.Qi-Pin Qin 1, Shu-Long Wang 1, Ming-Xiong Tan, *, Zhen-Feng Wang ,Dong-Mei Luo, Bi-Qun Zou**, Yan-Cheng Liu , Peng-Fei Yao ***, Hong Liang , ****,Novel tacrine platinum(II) complexes display high anticancer activity via inhibition of telomerase activity, dysfunction of mitochondria, and activation of the p53 signaling pathway[J] European Journal of Medicinal Chemistry, 158 (2018) 106-122
171. Qi-Pin Qin, Wang-Shu Long, Min-Xiong Tan, Zhen-Feng Wang, Xiao-Ling Huang, Qing-Min Wei, Bei-Bei Shi, Bi-Qun Zou * ,Hong Liang. Synthesis and antitumor mechanisms of two novel platinum (II) complexes with 3-(2'-benzimidazolyl)-7-methoxycoumarin[J]. Metallomics: integrated biometal science, 2018.10, 1160--1169 .
172. Qi-Pin Qin , Shu-Long Wang 1, Ming-Xiong Tan a, c, *, Yan-Cheng Liu , Ting Meng ,Bi-Qun Zou **, Hong Liang. Synthesis of two platinum(II) complexes with 2-methyl-8-quinolinol derivatives as ligands and study of their antitumor activities[J]European Journal of Medicinal Chemistry ,161 (2019) 334e342
173. Qi-Pin Qin, ?*Zhen-Feng Wang,? Ming-Xiong Tan, * Xiao-Ling Huang,Hua-Hong Zou, * Bi-Qun Zou, * Bei-Bei Shia and Shu-Hua Zhang *, Complexes of lanthanides(III) with mixed 2,20-bipyridyl and 5,7-dibromo-8-quinolinoline chelating ligands as a new class of promising anti-cancer agents[J] Metallomics, 2019, 11, 1005--1015
174.Guo-Bao Huang,? Shan Chen,?b Qi-Pin Qin, *Jin-Rong Luo,Ming-Xiong Tan, *Zhen-Feng Wang, Bi-Qun Zou * and Hong Liang*,In vitro and in vivo activity of novel platinum(II) complexes with naphthalene imide derivatives inhibiting human non-small cell lung cancer cells[J]New J. Chem., 2019,43, 8146
175. Bi-Qun Zou, Xing Lu , Qi-Pin Qin, Yu-Xia Bai, Ye Zhang, Yan-Cheng Liu, Zhen-Feng Chen and Hong Liang, Three novel transition metal complexes of 6-methyl-2-oxo-quinoline-3-carbaldehyde thiosemicarbazone: synthesis, crystal structure, cytotoxicity, and mechanism of action[J]. RSC Advances, 2017, 7(29): 17923-17933.
176. Bi-Qun Zou*, Qi-Pin Qin, Yu-Xia Bai, Qian-Qian Cao, Ye Zhang, Yan-Cheng Liu, Zhen-Feng Chen and Hong Liang, Synthesis and antitumor mechanism of a new iron(III) complex with 5,7-dichloro-2-methyl-8-quinolinol as ligands[J]. Med. Chem. Commun, 2017, 8(3): 633-639.
177. Qi-Pin Qin, Ting Meng, Min-Xiong Tan, Yan-Cheng Liu, Shu-Long Wang, Bi-Qun Zou*, and Hong Liang, Synthesis, characterization and biological evaluation of six highly cytotoxic ruthenium (II) complexes with 4′-substituted-2, 2′: 6′, 2′′-terpyridine[J]. Med. Chem. Commun, 2018, 9(3), 525-533.
178. Qi-Pin Qin 1, Bi-Qun Zou 1, Ming-Xiong Tan *, Shu-Long Wang, Yan-Cheng Liu , Hong Liang. Tryptanthrin derivatives copper (II) complexes with high antitumor activity by inhibiting telomerase activity, and inducing mitochondria-mediated apoptosis and S-phase arrest in BEL-7402[J]. New Journal of Chemistry, 2018, 42, 15479--15487
179. Qi-Pin Qin 1, Bi-Qun Zou 1, Ming-Xiong Tan *, Shu-Long Wang , Yan-Cheng Liu , Hong Liang. Platinum (II) complexes with rutaecarpine and tryptanthrin derivatives induce apoptosis by inhibiting telomerase activity and disrupting mitochondrial function[J]. MedChemComm, 2018.
180. Qi-Pin Qin,1, Bi-Qun Zou,1, Ming-Xiong Tan?, Dong-Mei Luo, Zhen-Feng Wang, Shu-Long Wang, Yan-Cheng Liu. High in vitro anticancer activity of a dinuclear palladium(II) complex with a 2?phenylpyridine ligand [J] Inorganic Chemistry Communications, 2018, 96, 106-110
181.张晓婷1，黄婉云1*，廖月英1，谭梦云1，潘成学2.新型安曲霉素类N-杂衍生物的合成及活性研究.合成化学. 2018, 26(10), 721-726.
182.张小蓉1，张晓婷1，黄婉云1，2*，潘成学2*.抗生素2，4-二乙酰基间苯三酚及其衍生物的绿色高效合成.合成化学. 2018, 26(3), 183-185.
183.王淑琴，黄婉云*，张小蓉，张晓婷，潘成学，哒嗪并[6,1-b]喹唑啉酮类化合物的合成及其生物活性.有机化学. 2020, 40, 959-968.
184.王妙,黄琳,苏燕,许英红,黄铃月,周小群,李芳耀*.丹皮酚噻唑类化合物的合成及其细胞毒性评价.化学通报, 2019, 82(7), 630-635.
185.庞富华,冯启柱,周异欢,白春凤,庄子晗,李芳耀*. 1,2,3-三唑磺胺类化合物的合成及抗菌活性.精细化工, 2019, 36(1), 106-110.
186.辛懋， 庞富华,黄琳,周小群,王萌迪， 李金林， 李芳耀*.新型丹皮酚嘧啶类化合物的合成及抗肿瘤活性.合成化学, 2020, 28(06), 483-490.
187.庞富华,龚红菲,王秀,李芳耀*,黄琳,林家逊.丹皮酚腙类化合物的合成及其抗菌活性.化学研究与应用, 2018, 30(1), 164-168.
188.马献力,黄琳,苏燕,龚红菲,庞富华,林家迅,李芳耀*. N-苄叉丹皮酚腙的合成及其抗菌活性.精细化工, 2017, 34(9), 1023-1029.
189.王玲(#);李居伟;杨扬(*),石蒜碱对Lewis肺癌小鼠的抑瘤作用及机制,武汉大学学报（理学版）, 2019, 65(4): 363-368.
190.李居伟(#),杨扬(*).石蒜碱诱导肺癌NCI-H460细胞凋亡作用及其机制.肿瘤防治研究, 2018(1): 5-8.
191.时海荣(#),杨扬(*).草果挥发油联合环磷酰胺对肝癌细胞增殖的影响.山东医药, 2017(41): 31-33.
192.付薛艳(#),黄羽静,王玲,杨扬(*).香叶醇联合对丙基苯甲醛抑制肝癌HepG2细胞增殖作用及机制研究.重庆医学,2019(6):921-924.
193.蒙杰雲，黄默涵，吕玉彬，谭相端*.二硫吡咯酮类衍生物的合成及抗菌活性研究[J].国际药学研究杂志, 2019, 46(11): 840-847.
194.刘金龙，于敏， 王素娟，张贵杰*.千根草的化学成分研究.中国中药杂志，2020，45(21)，5226-5231.
195.张永丽，潘其明，张贵杰*，梁东.山乌桕茎叶的化学成分研究.中国中药杂志，2019，44(17)，3738-3744.
196.张贵杰*，代禄梅，张斌，张永丽，王恒山，梁东.臭牡丹的化学成分研究. 2017, 42(24)，4788-4793.
197.梁俐兰，刘永明，苏何玲.微小RNA-10b在肿瘤发生发展中的作用.癌症进展2020,18(06):541-543+569.
198.岳鹏鹏，郭俊璠，于鸿浩，付灿，王小燕，高进涛*.基于CRISPR/cas9系统高效编辑小鼠Galt基因.生物技术通报, 2020，36（8）：235-242.
199.郭勇,茶多酚对骨组织细胞的影响及其在组织工程中的应用进展,国际生物医学工程杂志, 2020; 43:239-243.
200.高进涛，何荣安，莫文飞，连冬丽，黄小芳，张婉青.白藜芦醇对过氧化氢诱导的HaCaT细胞氧化应激损伤的保护作用,长江大学学报（自然版）, 2019,16(05):88-92.
授权的部分发明专利
1.张业，马献力，邝文彬，余砚成，黄日镇，3-苯并咪唑-2(1H)-喹啉酮衍生物及其制备方法和应用，中国, ZL201610078898.3.
2.张业，邝文彬，余砚成，2-氯-3-(1H-苯并咪唑-2-基)-喹啉衍生物其制备方法和应用，中国，ZL201610078947.3.
3.张业，义祥辉，方毅林，刘贤贤，3-希夫碱-2(1H)-喹啉酮衍生物及其制备方法和应用，中国，ZL.201210407465X.
4.张 业，义祥辉，刘贤贤，王 凯，芳香基乙酸类衍生物的制备方法，中国，ZL.201010608181.8.
5.马献力，张业，余砚成，邝文彬，2(1H)-喹啉酮磷酸酯衍生物及其制备方法和应用，中国，ZL201610299957.X.
6.于鸿浩，赵新全，郭志林，郭松长，曹俊虎，徐世晓,藏羚羊-牛种间体细胞核移植胚胎的构建与体外发育方法，中国，ZL 2010 1 0200550. X
7.郭志林，赵新全，于鸿浩，郭松长，曹俊虎，徐世晓.藏羚羊-山羊种间克隆胚胎构建与体外培养的方法，中国，ZL 2010 1 0201828. 5
8.梁成钦，陈旭，付明磊，周先丽，黄晓，罗琴，苏小建,程柳，文君.气－质联用测定罗汉果中有机磷农药残留的方法. ZL 2016 1 0227280.9.
9.唐海涛，潘英明，莫祖煜，张羽真.一种电化学合成磺酰基肼基吲哚化类合物的方法和应用，中国，ZL.201910486584.0
10.谭相端，吕良，蒙杰雲，等.N-芳基二硫吡咯酮脲类和氨基酯类衍生物及其制备化合应用，中国，ZL201911186804.4.
11.谭相端，段小群，刘文涛，等.一种N-芳基二硫吡咯酮-吡喃酮杂合衍生物及其制备方法和应用，中国，ZL201811565381.2.
12.邹登峰，陈素一，张小玲，黄晓.从金花茶中提取多糖的方法，中国，ZL201510707904.2.
13.邹登峰，陈素一，张小玲，黄晓.从金花茶叶中提取金花茶多糖的方法，中国，ZL201510707853.3.
14.邹登峰，陈素一,黄晓.金花茶多糖的提取方法，中国，ZL201510705138.6.
15.邹登峰，张小玲，黄晓.从金花茶叶中提取多酚的方法，中国，ZL201510573558.3.
16.邹登峰，陈素一，黄晓.从金花茶叶中提取多酚类物质的方法. (第一发明人，ZL201510573856.2）
17.邹登峰;朱华;柯珍;陈剑娇;王晓华.银杏内酯的提取方法，中国，ZL201810438920.X.
18.黄婉云，廖迎，彭湘艳，殷鹏龙，廖月英，二茂铁-喹诺酮酰胺类化合物及其制备方法和应用，中国,ZL201510172067.8.
19.张业，马献力，余砚成，韦健华，发明专利：11,12-二氯苯并咪唑-1,8-萘酰亚胺-铂配合物及其制备方法和应用，中国，ZL201810730055.6.
20.张业，马献力，余砚成，杨晨辉，发明专利：11-三氟甲基苯并咪唑-1,8-萘酰亚胺-铂配合物及其制备方法和应用，中国，ZL201810729763.8.
21.张业，马献力，余砚成，梁贵宾，发明专利：12-氯苯并咪唑-1,8-萘酰亚胺-铂配合物及其制备方法和应用，中国，ZL201810729521.9.
22.张业，余砚成，马献力，徐勤，发明专利：苯并咪唑-1,8-萘酰亚胺-铂配合物及其制备方法和应用，中国，ZL201810729771.2.
23.张业，马献力，余砚成，韦健华，发明专利：11,12-二甲基苯并咪唑-1,8-萘酰亚胺-铂配合物及其制备方法和应用，中国，ZL201810730052.2.
24.张业，马献力，余砚成，徐燕丽，杨晨辉，发明专利：12-氟苯并咪唑-1,8-萘酰亚胺-铂配合物及其制备方法和应用，中国，ZL201810730053.7.
科研奖励或个人荣誉
1.张业，第二十届广西十百千人才工程第二层次人选（桂政法[2017]42号），2017.
2.张业，广西高校卓越学者（桂教人[2017]38号），2017.
3.张业，第十三届广西青年科技奖（桂科协组发[2015]5号），2015.
4.张业，义祥辉，覃 雯，潘英明，王恒山，程忠泉，陈力健，基于白藜芦醇骨架改造的化合物的制备及其抗氧化、抗肿瘤活性研究（桂政发[2015]15号），广西科技进步奖三等奖，2015.
5.王恒山，潘英明，梁英，陈振锋，张业，徐燕丽，若干绿色催化体系在五元氮杂环药物骨架构筑及手性氮碳磷键侧链修饰中的应用（桂政发[2017]19号），广西自然科学进步奖二等奖，2017.
6.潘英明，王恒山，吴强，黄宇平，杨韶平，张业，王迎春，陈键泉，黄晓超，松香手性产品深加工技术及其生产工艺的研发与应用（桂政发[2016]17号），广西科技进步奖二等奖，2016.
7.谭明雄、邓旭、陈光全、黎霜、谭洪盛、韦忠孙、张业，吴茱萸、板蓝根等特色壮药研发、关键技术及应用（桂政发[2018]10号），广西科技进步奖三等奖，2018.