万博水晶宫

       朱峰，中共党员，医学博士，教授，桂林医学院附属医院肿瘤研究所主 任，桂林医学院学科带头人。1999年获第四军医大学博士学位，2000年赴新加坡分子细胞生物研究所做访问学者， 2002-2013年历任美国明尼苏达大学 Hormel研究所博士后、助理教授及副教授。2013年获聘湖北省“楚天学者”特聘教授，中国生物化学与分子生物学第六届理事，湖北省生物化学协会理事，美国AACR会员。研究方向为癌激酶与靶向治疗。回国后带领团队已获得国基金资助7项（面上4项，本人主持3项，青基2项，外青1项），省基金5项。以一作和通讯作者在Gastroenterology，Cancer Res，Clin Cancer Res，Oncogene，EBioMedicine，Carcinogenesis，Cell death and Disease，J BiolChem，J Clin Invest等国际知名期刊发表文章60余篇。参编学术专著2部。申请国内外发明专利9项，其中授权7项。主讲博士研究生培养及本科医学专业相关课程4门，培养博士后2名，博士研究生8名，硕士研究生7名。

【代表性研究成果】

(1) Li, Mingyang; Fan, Linni; Han, Donghui; Yu, Zhou; Ma, Jing; Liu, Yixiong; Li, Peifeng; Zhao, Danhui; Chai, Jia; Jiang, Lei; Li, Shiliang;Xiao, Juanjuan; Duan, Qiuhong; Ye, Jing; Shi, Mei; Nie, Yongzhan; Wu,Kaichun; Liao, Dezhong Joshua; Shi, Yu; Wang, Yan; Yan, Qingguo; Guo,Shuangping; Bian, Xiuwu; Zhu, Feng*; Zhang, Jian*; Wang, Zhe*; Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma, Journal of Clinical Investigation, 2020, 130(8): 4301-4319. (期刊论文)

(2) Tian, Qin; Yuan, Ping; Quan, Chuntao; Li, Mingyang; Xiao, Juanjuan; Zhang, Lu; Lu, Hui; Ma, Tengfei; Zou, Ling; Wang, Fei; Xue, Peipei; Ni, Xiaofang; Liu, Lin; Wang, Zhe*; Zhu, Feng*; Duan, Qiuhong*; Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis ofcolorectal cancer, Oncogene, 2020, 39(20): 3980-3996. (期刊论文)

(3) Xiao, Juanjuan#; Wang, Fei#; Lu, Hui; Xu, Sanpeng; Zou, Ling; Tian, Qin;Fu, Yang; Lin, Xuan; Liu, Lin; Yuan, Ping; Ni, Xiaofang; Ma, Tengfei; Zeng,Fanfan; Xue, Peipei; Xiu, Ruijuan; Zhang, Jianmin; Ji, Xinying; Hu, Hongbo; Lu,Shangyun; Dai, Hongtian; Li, Yuan; Chu, Qian*; Zhao, Xia*; Duan, Qiuhong*; Zhu,Feng*; Targeting the COX2/MET/TOPK signaling axis induces apoptosis in gefitinib-resistant NSCLC cells , Cell Death & Disease, 2019, 10: 0-777.(期刊论文)

(4) Lu H#, Xiao J, Ke C, Ni X, Xiu R, Tian Q, Pan H, Zou L, Wang F, Ma T, Ji X, Yuan P, Liu L, Zhang J, Jia W *, Duan Q *, Zhu F*. TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ. Cell Death Dis. 2019 Aug 5;10(8):583.(期刊论文)

(5) Xie, Hua#; Lee, Mee-Hyun#; Zhu, Feng#; Reddy, Kanamata; Peng, Cong; Li,Yan; Lim, Do Young; Kim, Dong Joon; Li, Xiang; Kang, Soouk; Li, Haitao; Ma,Weiya; Lubet, Ronald A.; Ding, Jian; Bode, Ann M.; Dong, Zigang*; Identification of an Aurora Kinase Inhibitor Specific for the Aurora B Isoform , Cancer Research, 2013, 73(2): 716-724. (期刊论文)

(6) Zhu, Feng#; Zykova, Tatyana A.#; Kang, Bong Seok; Wang, Zhe; Ebeling,Mara C.; Abe, Yasuhito; Ma, Wei-Ya; Bode, Ann M.; Dong, Zigang*; Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells, Gastroenterology, 2007, 133(1): 219-231. (期刊论文)

(7) Zykova Tatyana#; Zhu Feng#; Wang Lei; Li Haitao; Lim Do Young; Yao Ke; Roh Eunmiri; Yoon Sang Pil; Kim Hong Gyum; Bae Ki Beom; Wen Weihong; Shin Seung Ho; Nadas Janos; Li Yan; Ma Weiya; Bode Ann M; Dong Zigang*. Targeting PRPK Function Blocks Colon Cancer Metastasis, Molecular Cancer Therapeutics, 2018.05, 17(5): 1101~1113. (期刊论文)

(8) Peipei Xue#; Fanfan Zeng#; Qiuhong Duan#; Juanjuan Xiao; Lin Liu; Ping Yuan; Linni Fan; Huimin Sun; Olesya Malyarenko; Hui Lu; Ruijuan Xiu; Shaoqing Liu; Chen Shao; Jianmin Zhang; Wei Yan* ; Zhe Wang* ; Jianyong Zheng*; Feng Zhu*. BCKDK of BCAA catabolism cross-talking with the MAPK pathway promotes tumorigenesis of colorectal cancer, Ebiomedicine, 2017.5, 20: 50~60. (期刊论文)

(9) Li, Xiang#; Li, Haitao#; Li, Shengqing#; Zhu, Feng#; Kim, Dong Joon; Xie, Hua; Li, Yan; Nadas, Janos; Oi, Naomi; Zykova, Tatyana A.; Yu, Dong Hoon; Lee, Mee-Hyun; Kim, Myoung Ok; Wang, Lei; Ma, Weiya; Lubet, Ronald A.; Bode, Ann M.; Dong, Ziming; Dong, Zigang*, Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B, Carcinogenesis, 2012.12.01, 33(12): 2548~2557. (期刊论文)

【承担的主要科研项目】

（1）国家自然科学基金面上项目，81972762，Src 在Y246 磷酸化BCAA分解代谢的限速酶BCKDK，促进结直肠癌的转移，2020/01-2023/12，55 万元，在研，主持。

（2）国家自然科学基金面上项目，81672936，c-Met 磷酸化TOPK 促进非小细胞肺癌对TKI 耐药的机理研究，2017/01-2020/12，58 万元，结题，主持。

（3）国家自然科学基金面上项目，81472602，Src 在Y74、Y272 磷酸化TOPK对结肠癌发生的作用及机制研究，2015/01-2018/12，72 万元，结题，主持。