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YANG Yue

( Department of Anesthesiology, Jiaozuo Materal and Child Health Hospital, Jiaozuo 454000, China)

Abstract Objective To observe the application effects of preoperative atropine pretreatment in anesthesia forendometrial cancer surgery, Methods 115 patients with endometrial cancer were selected and randomly divided intotwo groups. 57 cases in the control group were received preoperative dexmedetomidine assisted general anesthesia. 58cases in the observation group were received preoperative atropine combined with dexmedetomidine as an auxiliarygeneral anesthesia. The changes in basic physical signs, preoperative and postoperative cognitive function scores.delirium occurrence, and postoperative recovery during the perioperative period were compared between two groupspatients. Results After anesthesia, the HR and MAP in the observation group at Tl and T0, T2 and T0, T3 and Towere signilficantly lower than those in the control group, showing a statistically significant difference ( P<0.05 ). TheMMSE and MoCA scores at T3, as well as the incidence of delirium at 1 h, 24 h, and 72 h after extubation, and there was no statistically significant difference compared to the control group ( P>0.05 ). The postoperative recoverytime . PACU retention time , and RSS score in the observation group were significantly lower than those on the controlgroup ( P<0.05). Conclusion Pre operative atropine pretreatment avoids fluctuations in perioperative signs inpatients with endometrial cancer, and improves awakening quality without affecting postoperative cognition or increasing anesthesia risk.

Keywords: endometrial cancer ; atropine ; dexmetomidine; awakening quality; postoperative delirium

DOI:10.19296/i.cnki.1008-2409.2024-04-031

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