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WU Wenhui¹, LlU Lin², CENG Beibei¹

(1. Department of Respiratory Medicine, Xinzheng Huaxin People's Hospital, Xinzheng 451100 ,China;2. Department of Respiratory Medicine, Zhengzhou 

People's Hospital, Zhengzhou 450000, China)

Abstract Objective To investigate the elfects of aminophylline injection combined with terbutaline and salbutamolin the elderly patients with bronchial asthma( BA ). Methods 86 elderly patients with BA were randomly divided intothe conventional group and combined group, with 43 cases in each group. The patients in the conventional groupwere treated with terbutaline and salbutamol inhalation, and the patients in the combined group were treated with aminophyline on the basis of the conventional group. The clinical efficacy, disappearance time of clinical symptomslung function , asthma control, airway inflammatory factors, immune funetion , adverse reactions and recurrence werecompared the between conventional group and combined group. Results After treatment, the total effective rate incombined group was 93.02%, which was higher than 76.74% in conventional group, showing a statisticallysignificant diference( P<0.05 ). The disappearance time of asthma, wheezing sound and cough in combined groupwere shorter than those in conventional group ( P<0.05). FEV1 ,PEF, FEV1/FVC, ACT scores, IgA , IgG and IgM in combined group were obviously higher than those in conventional group, and the levels of phlegm and peripherablood eosinophil ( EOS ), IL-17,TGF-0 and IgE in sputum in combined group were obviously lower than those inconventional group ( P<0.05 ). During treatment, the overall ineidence of adverse reactions was not different betweenthe conventional group and combined group ( P> 0.05 ). After 6 months of follow-up, the recurrence rate in thecombined group was obviously lower than that in eonventional group ( P<0.05 ) .Conclusion Aminophylline combinedwith salbutamol and terbutaline has definite clinical efficacy in the elderly patients with BA, which controlselflectively the progression of asthma, improves lung function, reduces the degree of airway inflammation, correctsimmune dysfunction, and reduces the recurrence rate.

Keywords: bronchial asthma; aminophylline injection; terbutaline ; salbutamol

DOI:10.19296/i.cnki.1008-2409.2024-04-029

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