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LIU Zhiqiang^a, SONG Jiale^bc, ZHOU Yanyuana^de

( a. College of Pharmacy, b. College of Public Health, c. Guangxi Key Laboratory of Enviromental Exposomics and Entire Lifecycle Health, d. Guangxi Key Laboratory of Drug Discovery and Optimization, e. Guangxi Engineering Research Center for Pharmaceutical Molecular Screeing and Drugability Evaluation, Guilin Medical University, Guilin 541199, China) 

Abstract Nasopharyngeal carcinoma ( NPC ) is a malignant tumor that develops in the mucosal epithelium of the nasopharynx and is characterized by easy recurrence, early metastasis and high degree of malignancy. At present, clinical treatment of NPC is mainly based on radiotherapy or chemotherapy, but it causes adverse reactions such as diarrhea and hair loss, which seriously affect the quality of life of patients.The emergence of drug resistance is the main reason for the treatment failure of advanced NPC. Flavonoidsbelong to the secondary metabolites of plants and have good activities such as anti-tumor, anti-inflammatory and anti-oxidant. In recent years, studies on the mechanism of anti-NPC of flavonoids have gradually deepened and made significant progress. This mainly focuses on these aspects, in which flavonoids inhibit the proliferation of NPC cells, induce apoptosis of NPC cells, regulate the signaling pathway of NPC as well as increase the sensitivity of NPC to radiotherapy and chemotherapyt. This paper provides a brief review on the progress of research on the mechanism of action of flavonoids in the prevention and treatment of NPC, in order to provide more scientific ideas and bases for the subsequent in-depth research and rational clinical application.

Keywords: flavonoids; nasopharyngeal carcinoma; proliferation; apoptosis; signaling pathway

DOI:10.19296/j.cnki.1008-2409.2024-03-004

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