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WANG Jing, CHEN Qian

( The First Departent of Paediatrics , Zhumadian Central Hospital, Zhumadian 463000, China)

AbstractObjective 'To observe the efficaey and safety of sequential therapy of cephalosporin in children withpneumonia. Methods 1 10 children with pneumonia were selected and divided into two groups using a random numbertable method, with 55 cases in each group. The conventional group were treated with routine drugs, and thesequential group were treated with cephalosporin. "The symptom relief time, inflammatory factors, immune indieators,drug safety and medical costs of the two groups were compared. Results After treatment, the relief time of symptomssuch as cough, inspiratory triple concave sign, and fever in the sequential group was lower than that in theconventional group, and the bacterial clearance rate in the sequential group was higher than that in the conventionalgroup, with a statistically significant differences( P<0.05 ); the levels of CD3* and CD4* in the sequential group were higher than those in the conventional group, while the level of Cl8* was lower than that in the conventionalgroup( P<0.05 ) ; the ineidence of C-reactive protein( CRP) , procalcitonin( PCT) , interleukin 6 ( lL-6) and drugrelated adverse reactions in the sequential group were lower than those in the conventional group; the hospitalizationtime, total treatment duration, and total medical expenses of the sequential group were all lower than those of theconventional group( P<0.05 ). Conclusion "The sequential therapy of cephalosporin can speed up the rehabilitationprocess of children with pneumonia, and has positive significance in enhancing the body immunity, alleviatinginflammatory reaction , improving drug safety and reducing medical costs.Keywords: children with pneumonia; cephalosporin ; sequential therapy; rehabilitation process ; drug safety

DOI:10.19296/j.cnki.1008-2409.2024-02-030

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