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ZHA0 Ge¹, CHEN Zhingong¹, YANG Yansong¹, LI Taiping¹, Ll Jiajun²

(1.Departement of Neurosurgery, Zhengzhou Yihe Hospital, Zhengzhou 450047, China;2.Departement of Medical Yangtze University, Jingzhou 434023. China)

Objective To observe the short-tem and long-term effects of Temozolomide( TMZ )A bstractchemotherapy and radioknife radiotherapy in patients with glioma after surgery. Methods 87 patients withglioblastoma were selected and divided into the chemotherapy group(43 cases) and radiotherapy group(44 cases)by drawing lots. The chemotherapy group were received TMZ chemotherapy, while theradiotherapy group were received radioknife radiotherapy. The changes in various biomarker levels and lesion improvement after treatment were compared between the two groups, as well as the quality of life andincidence of adverse events during the follow-up period. Results After treatment, there was no statisticallysignificant difference in the levels of carbohydrate antigen 153 ( CA153), neuron specifie enolase ( NSE )asparagine endopeptidase ( AEP), tumor proliferation marker ( Ki-67), objective response rate (ORR),and disease control rate ( DCR) between the two groups of patients ( P>0.05 ). During the follow-upperiod, the Karnofsky performanee status ( KPS) and quality of life score ( Q0L) of tumor patients in theradiotherapy group were higher than those in the chemotherapy group, while the zubrod performance status(ZPS) was lower than that in the chemotherapy group. The incidence of adverse events was lower than thatin the chemotherapy group, and the differences were statistically significant ( P<0.05 ). Conclusion Theapplication of 'TMZ, chemotherapy or radioknife radiotherapy has positive significanee in controlling thepostoperative progression of glioma patients, but radioknife radiotherapy has clinical advantages inimproving patient quality of life and reducing the risk of adverse events.Keywords: glioma; craniotomy; temozolomide chemotherapy; wave knife radiotherapy

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