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GU0 Chuanzhi, LI Kongdong, GU Jie( College of Life Seiences, Jiangsu University, Zhenjiang 212013, China)

Abstract Heavy metal pollution has intensified worldwide and poses an inereasing threat to humanity.

Metal ions enter the body and accumulate in vital body organs such as the liver, heart, kidneys and brain.

disrupting their normal biological funetions. Diabetie nephropathy ( DN)is a common kidney disease. lnaddition to genetics, the environmental factors have gradually become a major cause of promoting thedevelopment of DN. In reeent years, the studies have shown that exposure to heavy metals inereases therisk of DN. In this paper, the elfeets of ferrum , cadmium, lead and other heavy metal ions on diabeticnephropathy , oxidative stress and the mediating role of metallothionein in diabetie nephropathy indueed byheavy metal ions, and the role of metallothionein's main metal zine in delaying diabetie nephropathythrough anti-oxidation are reviewed, providing theoretical basis and reference for the prevention andtreatment of diabetie nephropathy in the future.

Keywords: heavy metals: diabetic nephropathy: oxidative stress

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