溶栓联合替罗非班治疗急性脑梗死患者的效果观察
摘要：目的：探究溶栓后24 h内联合替罗非班治疗急性脑梗死患者的效果。方法：选取80例急性脑梗死患者，按随机数字表法分为对照组和观察组，每组各40例。对照组给予溶栓+阿司匹林治疗，观察组给予溶栓+替罗非班治疗，比较两组美国国立卫生研究院卒中量表（NIHSS）评分、RANKIN量表（mRS）评分、再次梗死率、脑出血率、其他部位出血率与治疗效果。结果：治疗后，观察组NIHSS评分、mRS评分均低于对照组（P＜0.05）;其他部位出血率低于对照组（P＜0.05）;治疗30 d后，观察组治疗总有效率97.5%高于对照组的82.5%（P＜0.05）;两组再次梗死、脑出血情况没有统计学差异（P＞0.05）。结论：溶栓后24 h内联合替罗非班可改善急性脑梗死患者神经功能，提高治疗效果。
Effect of thrombolytic therapy combined with tirofiban onpatients with acute cerebral infarction①
GAO Yang,LIU Yingying.(Ward Ⅱ of Dept. of Neurology,the 9thPeople′s Hospital of Zhengzhou,Zhengzhou 450000,China)
Abstract Objective: To investigate the efficacy of tirofiban in the treatment of patients with acute cerebral infarction within 24 hours after thrombolysis. Methods: 80 patients with acute cerebral infarction were randomized into the control and observation group, with 40 cases in each group. The control group were treated with thrombolysis and aspirin, while the observation group were treated with thrombolysis and tirofiban. NIH Stroke Scale ( NIHSS ), Modified RANKIN Scale ( MRS ), reinfarction rate, cerebral hemorrhage rate, bleeding rate in other sites, and clinical effect were compared in patients between both groups. Results: After treatment, the NIHSS and mRS scores in the observation group were lower than those in the control group(P<0.05); the bleeding rate in other sites of the observation group was lower than that of the control group(P<0.05); after 30 days of treatment, the total effective rate of observation group was 97.5%, higher than 82.5% of control group(P<0.05); and there was no statistical difference of the reinfarction rate and cerebral hemorrhage rate between both groups (P> 0. 05). Conclusion: The combined treatment with tirofiban within 24 hours after thrombolysis can improve the neurological function and therapeutic effect of patients with acute cerebral infarction.
Keywords:tirofiban; thrombolytic therapy; acute cerebral infarction
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