持续皮下胰岛素输注联合维格列汀治疗2型脆性糖尿病的临床研究
郭明月 白倩
南阳市中心医院内分泌科
摘要：目的：探讨持续皮下胰岛素输注（CSII）联合维格列汀在2型脆性糖尿病患者中的应用效果。方法：选取2型脆性糖尿病患者64例，按照随机数字表法分为对照组和观察组，每组各32例。对照组采用CSII联合安慰剂治疗，观察组采用CSII联合维格列汀治疗。分析两组血压、胰岛素日用量、血糖、血清氧化应激指标及不良反应。结果：治疗3个月后，观察组SBP、DBP、胰岛素日用量、血糖、血糖波动及活性氧（ROS）水平均低于对照组（P＜0.05）;观察组谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）、总抗氧化能力（T-AOC）水平高于对照组（P＜0.05）;两组不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论：CSII联合维格列汀治疗2型脆性糖尿病患者，可有效稳定调节血糖，提高治疗效果。
关键词：胰岛素;维格列汀;2型脆性糖尿病;氧化应激;
Effect of composite acid combined with Pure gold radiofrequency fire needle on patients withmoderate and severe facial acne
ZUO Yuhui,TAN Fenfang,TAN Xia,LIANG Limei,LIANG Meixin.(Dept. of Dermatology,Guiping People′s Hospital,Guiping 537200,China)
Abstract Objective: To observe the clinical effect of composite acid combined with Pure gold radiofrequency fire needle on patients with moderate and severe facial acne. Methods: A total of 114 patients with acne were selected and divided into the observation group and control group alternately according to the order of treatment, with 57 cases in each group. The control group were treated with composite acid, while the observation group were treated with Pure gold radiofrequency fire needle on the basis of composite acid. Then, the clinical efficacy, the skin lesions (inflammatory papules, pustules,nodules and cysts), trans-epidermal water loss (TEWL), water content of stratum corneum of skin,erythema value, and pH value and the occurrence of adverse reactions were compared between the two groups. Results: Four weeks after treatment, the treatment efficiency of observation group was significantly higher than that of the control group(P<0.05); the number of skin lesions in both groups decreased, and the number of skin lesions in observation group was less than that in control group(P<0.05); TEWL anderythema value of the observation group was significantly lower than that of the control group(P<0.05),and the water content of stratum corneum and pH value was higher than that of the control group,indicating that skin barrier was well improved(P<0.05). Conclusion: The application of composite acid combined with Pure gold radiofrequency fire needle can significantly improve the therapeutic effect onpatients with moderate and severe facial acne.
Keywords: composite acid; Pure gold radiofrequency fire needle; acne
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