通心络胶囊联合芪苈强心胶囊治疗慢性心力衰竭患者的效果观察①
张一帆 ② ,杨清泉,冯文化,王伟民 ③
(南阳市中心医院,河南 南阳 473000)
摘要 目的:探究通心络胶囊联合芪苈强心胶囊治疗慢性心力衰竭患者的临床效果。 方法:选取 86例慢性心力衰竭患者,按照随机数字表法分为观察组和对照组,每组各 43 例。 对照组采用芪苈强心胶囊治疗,观察组在对照组基础上加用通心络胶囊治疗。 观察两组治疗效果、血浆 BNP 水平、血管内皮功能、心功能及不良反应。 结果:观察组总有效率高于对照组,两组比较差异有统计学意义(P<0.05);治疗后,观察组血浆 BNP 水平低于对照组,观察组血管内皮生长因子(VEGF)、NO 水平高于对照组,两组比较差异有统计学意义(P<0.05);观察组左心室射血分数(LVEF)高于对照组,左心室舒张末期内径(LVEDD)低于对照组(P<0.05);两组均未出现明显的不良反应。 结论:通心络胶囊联合芪苈强心胶囊治疗慢性心力衰竭患者,效果显著,可以改善血管内皮功能及心功能,且安全性高。
关键词: 慢性心力衰竭;通心络胶囊;芪苈强心胶囊;血管内皮功能;心功能
中图分类号:R714.252 文献标志码:A 文章编号:1008-2409(2022)03-0010-05
Effects of Tongxinluo capsule combined with Qiliqiangxin capsule on patients with chronic heart
failure ①
ZHANG Yifan ② , YANG Qingquan, FENG Wenhua, WANG Weimin ③ . ( Nanyang CentralHospital, Nanyang 473000, China)
Abstract Objective: To explore the clinical effect of Tongxinluo capsule combined with Qiliqiangxin capsule on patients with chronic heart failure. Methods: 86 patients with chronic heart failure were randomized into the observation group and control group, each with 43 cases. The control group were administered with Qiliqiangxin capsule, while the observation group were treated with Tongxinluo capsule on the basis of the treatment for the control group. The therapeutic effect, plasma BNP level, vascular endothelial function, cardiac function and adverse reactions were compared between the two groups. Results: The total effective rate of the observation group was higher than that of the control group, and the difference was significant (P<0.05);after treatment, the plasma BNP level in the observation group was lower than that in the control group, and the levels of vascular endothelial growth factor(VEGF)and nitric oxide(NO)in the observation group were higher than those in the control group, which were of statistical differences(P<0.05); the left ventricular ejection fraction(LVEF)in the observation group was higher than that in the control group, and the left ventricular end diastolic diameter(LVEDD)was lower than that in the control group(P<0.05); and there were no adverse reactions in the two groups. Conclusion:Tongxinluo capsule combined with Qiliqiangxin capsule can improve the therapeutic effect of patients with chronic heart failure, promote the improvement of vascular endothelial function and cardiac function. Besides, it is of high safety.
Keywords: chronic heart failure; Tongxinluo capsule; Qiliqiangxin capsule; vascular endothelial function; cardiac function
参考文献:
[1] 杨帆,于淑华,孙冰岩,等.芪苈强心胶囊治疗冠心病慢性心力衰竭的效果及对心功能、生活质量的影响[J].临床误诊误治,2021,34(9):24-28.
[2] 石宝星,胡伟.芪苈强心胶囊联合心脏康复对慢性心力衰竭患者心功能和心室重构的影响[J].中国循证心血管医学杂志,2020,12(4):470-472.
[3] 陈佳斌,秦佳枫,赵钢.慢性心力衰竭的中西医发病机制及其治疗进展[J].中西医结合心脑血管病杂志,2019,17(3):378-380.
[4] 杨燕,贺小芳,刘小芸,等.芪苈强心胶囊辅助西医常规疗法治疗冠心病慢性心力衰竭系统评价[J].中国中医药信息杂志,2021,28(2):39-45.
[5] 中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.慢性心力衰竭基层诊疗指南(2019 年)[J].中华全科医师杂志,2019,18(10):936-947.
[6] 郑筱萸.中药新药临床研究指导原则(试用版)[M].北京:中国医药科技出版社,2002:78-79.
[7] 赵海云,刘兴河.常规抗心力衰竭治疗加用芪苈强心胶囊治疗慢性心力衰竭的疗效评价[J]. 吉林医学,2019,40(8):1812-1813.
[8] 刘欢,李玮吉.芪苈强心胶囊对慢性心力衰竭患者心功能、血浆 BNP、PRA、IL-6 水平的影响[J].湖北中医药大学学报,2021,23(5):59-61.
[9] 姚素敏.芪苈强心胶囊治疗扩张型心肌病所致慢性心力衰竭的效果观察[J].河南医学研究,2018,27(6):1059-1060.
[10] WAWRZENCZYK A,ANASZEWICZ M,WAWRZENCZYK A,et al.Clinical significance of nutritional status in patients with chronic heart failure—a systematic review[J].Heart Fail Rev,2019,24(5):671-700.
[11] 季洁,王莹,赵红.通心络胶囊联合磷酸肌酸钠治疗慢性心力衰竭的临床研究[J]. 现代药物与临床,2019,34(7):1988-1992.
[12] 潘有龙,李晓莉.通心络胶囊联合 β-受体阻滞剂及其他抗心衰药物对老年高血压合并慢性心力衰竭患者心功能的影响[J].临床医学研究与实践,2021,6(2):32-34.
[13] ZHOU J,WANG Z,HE Y,et al.Qiliqiangxin reduced cardiomyocytes apotosis and improved heart function in infarcted heart through Pink1/ Parkin-mediated mitochondrial autophagy[J].BMC Complement Med Ther,2020,20(1):203.
[14] 赵娜,齐新.芪苈强心胶囊治疗慢性心力衰竭的临床疗效观察[J].中西医结合心脑血管病杂志,2018,16(8):1001-1004.
[15] ZHANG F G, ZHANG Y, LI X F, et al. Research on Q-markers of Qiliqiangxin capsule for chronic heart failure treatment based on pharmacokinetics and pharmacodynam-ics association[J]. Phytomedicine,2018,25(15):220-230.
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