多次蓝光疗法与连续蓝光疗法治疗新生儿黄疸的效果及对总胆红素、游离胆红素的影响①
张 网 ② , 徐 霞 ③
(驻马店市中心医院新生儿重症医学科,河南 驻马店 463000)
摘要 目的:探究多次蓝光疗法与连续蓝光疗法治疗新生儿黄疸的效果及对总胆红素(TBIL)、游离胆红素(IBIL)的影响。 方法:选取 77 例新生儿黄疸患儿,按照随机数字表法分为 A 组 39 例和 B 组 38 例。 两组患儿均给予血液碱化、补液等黄疸基础治疗,在此基础上,A 组使用多次蓝光间歇照射治疗,B 组使用持续蓝光照射治疗。 对比两组临床疗效、血清 TBIL、IBIL 水平和不良反应。 结果:治疗后,A 组总有效率高于 B 组(P<0.05);A 组血清 TBIL、IBIL 水平明显低于 B 组(P<0.05);A 组不良反应总发生率低于 B 组,两组比较差异有统计学意义(P<0.05)。 结论:采用多次蓝光疗法治疗新生儿黄疸效果显著,安全性更好。
关键词: 新生儿黄疸;蓝光疗法;总胆红素;游离胆红素
中图分类号:R722.17 文献标志码:A 文章编号:1008-2409(2022)03-0015-04
Effects of multiple blue light therapy and continuous blue light therapy on neonatal jaundice and its impact on total bilirubin and free bilirubin ①
ZHANG Wang ② , XU Xia ③ .(Dept. of Neonatal Intensive Medicine,Zhumadian Central Hospital,Zhumadian 463000, China)
Abstract Objective: To explore the effects of multiple blue light therapy and continuous blue light therapy on neonates with jaundice and its impact on total bilirubin(TBIL)and indirect bilirubin(IBIL). Methods: 77 neonates with jaundice were randomly divided into two groups: 39 cases in Group A and 38 cases in Group B. Both groups were given such basic treatment of jaundice as blood alkalization and rehydration. On this basis, Group A received multiple intermittent blue light irradiation therapy, while Group B were treated with continuous blue light irradiation. Then, the clinical therapeutic effects, levels of serum TBIL and IBIL of the two groups were compared. Results: After treatment, the total effective rate was higher than that of Group B(P<0.05); levels of serum TBIL and IBIL in Group A were significantly lower than those of Group B(P<0.05); and the total incidence of adverse reactions in Group A was lower than that in Group B, with statistical difference(P<0.05). Conclusion: The adoption of multiple blue light therapy for neonates with jaundice is better and safer.
Keywords: neonatal jaundice; blue light therapy; total bilirubin(TBIL); indirect bilirubin(IBIL)
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