新生儿病理性黄疸的相关危险因素分析
方亚男,张艳星,袁巧云
(许昌龙耀医院儿科,河南 许昌 461700)
摘要 目的:采用 Logistic 回归方程分析新生儿病理性黄疸的影响因素。 方法:选取 355 例新生儿,统计病理性黄疸发生情况,收集临床资料,分析新生儿病理性黄疸的危险因素。 结果:355 例新生儿中,发生病理性黄疸的新生儿为 81 例,未发生的新生儿为 274 例,新生儿病理性黄疸发生率为22.82%;不同早产情况、合并 ABO 溶血、宫内感染、缺氧缺血性脑病、Apgar 评分、白蛋白水平的新生儿病理性黄疸发生率差异有统计学意义(P<0.05);早产、合并 ABO 溶血、宫内感染、缺氧缺血性脑病、Apgar 评分<7 分、白蛋白水平<25 g/ L 均为新生儿病理性黄疸的独立危险因素(P<0.05)。 结论:新生儿病理性黄疸危险因素较多,临床应针对其危险因素采取综合性措施进行积极干预,预防新生儿病理性黄疸发生。
关键词: 新生儿;病理性黄疸;影响因素
中图分类号:R722.17 文献标志码:A 文章编号:1008-2409(2022)03-0052-05
Related risk factors of neonatal pathological jaundice
FANG Yanan, ZHANG Yanxing, YUAN Qiaoyun. ( Dept. of Pediatrics, Xuchang Longyao Hospital, Xuchang 461700, China)
Abstract Objective: To analyze the influencing factors of neonatal pathological jaundice by logistic regression equation. Methods: A total of 355 neonates were selected, and the incidence of pathological jaundice was counted and the clinical data of the patients were collected so as to analyze the risk factors of neonatal pathological jaundice. Results: Among the 355 neonates, 81 neonates developed pathological jaundice, while 274 neonates did not, and the incidence of neonatal pathological jaundice was 22.82%. The incidence of pathological jaundice in neonates with different preterm conditions, complicated with ABO hemolytic, intrauterine infection, hypoxic-ischemic encephalopathy, Apgar scores, and albumin level showed statistical significances(P<0.05). Neonates with preterm conditions, complicated with ABO hemolytic, intrauterine infection, hypoxic-ischemic encephalopathy, Apgar score less than 7, and albumin level less than 25 g/ L are all considered as the independent risk factors for neonatal pathological jaundice (P<0.05). Conclusion: There are many risk factors for neonatal pathological jaundice, so comprehensive measures should be taken to prevent the occurrence of neonatal pathological jaundice.
Keywords: neonates; pathological jaundice; influencing factors
参考文献:
[1] 黄开平,王荣芬,刘云昇.DTI 技术测定新生儿病理性黄疸患儿小脑齿状核 FAVR 与病情的关系及预测 ABE 价值[J].河北医学,2021,27(3):480-486.
[2] 汤丽,许欣.新生儿病理性黄疸患儿血清胆红素、TBA 及HS-CRP 检测水平分析 [J]. 中国实验诊断学,2018,22(9):1518-1521.
[3] LIU Y, SUN X, WANG Y, et al. Evaluationof associated markers of neonatal pathological jaundice due to bacterial infection[J].Iran J Public Health,2021,50(2):333-340.
[4] 周家兴.新生儿病理性黄疸患儿血清转铁蛋白、C-反应蛋白及红细胞免疫功能指标变化情况[J].中国妇幼保健,2019,34(2):335-336.
[5] 贺健.新生儿黄疸患儿治疗前后血清 TRF、CRP 及胆红素水平变化及其临床意义[J].标记免疫分析与临床,2019,26(2):290-293.
[6] THIELEMANS L,PEERAWARANUN P,MUKAKA M,et al.High levels of pathological jaundice in the first 24 hours and neonatal hyperbilirubinaemia in an epidemiological cohort study on the Thailand-Myanmar border[J].PLoS One,2021,16(10):e0258127.
[7] 刘元进,沈宁佳,张永杰.大鼠梗阻性黄疸后不同时间行胆道引流对肝脏功能及组织病理的影响[J].肝胆胰外科杂志,2019,31(9):549-556.
[8] TOPAL I,MERTOGLU C,SURUCU KARA I,et al.Thiol-disulfide homeostasis, serum ferroxidase activity, and serum ischemia modified albumin levels in neonatal jaundice[J].Fetal Pediatr Pathol,2019,38(2):138-145.
[9] 刘密,石光莲,姚欣.行为护理干预在新生儿黄疸中的护理效果及对母乳喂养率的影响[J].检验医学与临床,2019,16(18):2686-2687.
[10] SALIA S M,AFAYA A,WUNI A,et al.Knowledge,attitudes and practices regarding neonatal jaundice among caregivers in a tertiary health facility in Ghana[J].PLoS One,2021,16(6):e0251846.
[11] 邓婉,周玉娥,刘天云,等.碳氧血红蛋白在新生儿 ABO溶血性黄疸中的临床意义[J].昆明医科大学学报,2021,42(5):143-146.
[12] 姚超峰.脐带血血清总胆红素检测在新生儿 ABO 溶血病早期诊治中的临床价值[J].河北医学,2018,24(5):730-734.
[13] 廖宗琳,陈丽霞,沈宏志,等.围产期孕妇生殖道 B 族链球菌感染的影响因素分析及对妊娠结局的影响[J].中华医院感染学杂志,2018,28(2):247-249,253.
[14] 吴小春,唐丽娟.妊娠晚期孕妇生殖道感染病原微生物培养状况及妊娠结局分析[J].中国妇幼保健,2019,34(20):4753-4756.
[15] 侯立维,孔丽娜,杜开先.外源性胆红素对缺血缺氧性脑损伤大鼠认知功能及海马组织中蛋白酪氨酸激酶2/ 信号转导子与激活子 3/ B 细胞淋巴瘤基因-2 通路的影响[J].新乡医学院学报,2018,35(12):1052-1057.
[16] WANG Q,LV H,LU L,et al.Neonatal hypoxic-ischemic encephalopathy:emerging therapeutic strategies based on pathophysiologic phases of the injury[J]. J Matern Fetal Neonatal Med,2019,32(21):3685-3692.
[17] 梁颖,董小英,张玉玲,等.缺氧缺血性脑病新生儿短期 预后情况相关影响因素调查分析[J].中国妇幼保健,2020,35(7):1322-1324.
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